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Article

Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain

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Laboratory of Integrative Physiology, Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia
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Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain
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Department of Microbiology and Parasitology, Research Institute on Chemical and Biological Analysis, University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain
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Higher Institute of Applied Biological Sciences of Tunis, University of Tunis El Manar, 9, Rue Zouhair Essafi, 1006 Tunis, Tunisia
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CRETUS Centre, Department of Applied Physics, Faculty of Physics, University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain
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ELEDIA Research Center, DISI, University of Trento, 38123 Trento-Alto Adige, Italy
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CRETUS Centre, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Joseph Orgel
Int. J. Mol. Sci. 2021, 22(10), 5103; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105103
Received: 10 March 2021 / Revised: 23 April 2021 / Accepted: 10 May 2021 / Published: 12 May 2021
(This article belongs to the Special Issue Biological Effects of Non-ionizing Radiation)
Brain tissue may be especially sensitive to electromagnetic phenomena provoking signs of neural stress in cerebral activity. Fifty-four adult female Sprague-Dawley rats underwent ELISA and immunohistochemistry testing of four relevant anatomical areas of the cerebrum to measure biomarkers indicating induction of heat shock protein 70 (HSP-70), glucocorticoid receptors (GCR) or glial fibrillary acidic protein (GFAP) after single or repeated exposure to 2.45 GHz radiation in the experimental set-up. Neither radiation regime caused tissue heating, so thermal effects can be ruled out. A progressive decrease in GCR and HSP-70 was observed after acute or repeated irradiation in the somatosensory cortex, hypothalamus and hippocampus. In the limbic cortex; however, values for both biomarkers were significantly higher after repeated exposure to irradiation when compared to control animals. GFAP values in brain tissue after irradiation were not significantly different or were even lower than those of nonirradiated animals in all brain regions studied. Our results suggest that repeated exposure to 2.45 GHz elicited GCR/HSP-70 dysregulation in the brain, triggering a state of stress that could decrease tissue anti-inflammatory action without favoring glial proliferation and make the nervous system more vulnerable. View Full-Text
Keywords: 2.45 GHz radiation; GFAP; glucocorticoid receptor; HSP-70; nonionizing radiation 2.45 GHz radiation; GFAP; glucocorticoid receptor; HSP-70; nonionizing radiation
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MDPI and ACS Style

Othman, H.; López-Furelos, A.; Leiro-Vidal, J.M.; Ammari, M.; Sakly, M.; Abdelmelek, H.; Salas-Sánchez, A.Á.; Ares-Pena, F.; López-Martín, E. Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain. Int. J. Mol. Sci. 2021, 22, 5103. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105103

AMA Style

Othman H, López-Furelos A, Leiro-Vidal JM, Ammari M, Sakly M, Abdelmelek H, Salas-Sánchez AÁ, Ares-Pena F, López-Martín E. Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain. International Journal of Molecular Sciences. 2021; 22(10):5103. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105103

Chicago/Turabian Style

Othman, Haifa, Alberto López-Furelos, José M. Leiro-Vidal, Mohamed Ammari, Mohsen Sakly, Hafedh Abdelmelek, Aarón Á. Salas-Sánchez, Francisco Ares-Pena, and Elena López-Martín. 2021. "Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain" International Journal of Molecular Sciences 22, no. 10: 5103. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105103

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