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Glucose Metabolism in Burns—What Happens?

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Department of Anatomy and Embryology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, Romania
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Department of Plastic and Reconstructive Surgery, Life Memorial Hospital, 365 Grivitei Street, 010719 Bucharest, Romania
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Department of Biochemistry, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, Romania
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Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, Romania
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Department of Plastic and Reconstructive Surgery, Faculté de Médicine Toulouse-Rangueil 3, Université Toulouse III—Paul Sabatier, Rue de Languedoc, CEDEX 04, 31000 Toulouse, France
*
Authors to whom correspondence should be addressed.
Academic Editors: Julia Kzhyshkowska and David A. Hart
Int. J. Mol. Sci. 2021, 22(10), 5159; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105159
Received: 22 March 2021 / Revised: 7 May 2021 / Accepted: 10 May 2021 / Published: 13 May 2021
(This article belongs to the Special Issue Molecular and Biochemical Aspects in Burns)
Severe burns represent an important challenge for patients and medical teams. They lead to profound metabolic alterations, trigger a systemic inflammatory response, crush the immune defense, impair the function of the heart, lungs, kidneys, liver, etc. The metabolism is shifted towards a hypermetabolic state, and this situation might persist for years after the burn, having deleterious consequences for the patient’s health. Severely burned patients lack energy substrates and react in order to produce and maintain augmented levels of glucose, which is the fuel “ready to use” by cells. In this paper, we discuss biological substances that induce a hyperglycemic response, concur to insulin resistance, and determine cell disturbance after a severe burn. We also focus on the most effective agents that provide pharmacological modulations of the changes in glucose metabolism. View Full-Text
Keywords: glucose metabolism; burns; hypermetabolic state; hyperglycemia; insulin resistance glucose metabolism; burns; hypermetabolic state; hyperglycemia; insulin resistance
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MDPI and ACS Style

Badoiu, S.C.; Miricescu, D.; Stanescu-Spinu, I.-I.; Ripszky Totan, A.; Badoiu, S.E.; Costagliola, M.; Greabu, M. Glucose Metabolism in Burns—What Happens? Int. J. Mol. Sci. 2021, 22, 5159. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105159

AMA Style

Badoiu SC, Miricescu D, Stanescu-Spinu I-I, Ripszky Totan A, Badoiu SE, Costagliola M, Greabu M. Glucose Metabolism in Burns—What Happens? International Journal of Molecular Sciences. 2021; 22(10):5159. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105159

Chicago/Turabian Style

Badoiu, Silviu C., Daniela Miricescu, Iulia-Ioana Stanescu-Spinu, Alexandra Ripszky Totan, Silvia E. Badoiu, Michel Costagliola, and Maria Greabu. 2021. "Glucose Metabolism in Burns—What Happens?" International Journal of Molecular Sciences 22, no. 10: 5159. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105159

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