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Article

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

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Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan
2
Department of Medicine, Chang Gung University, Linkow 333, Taiwan
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Graduate Institute of Food Culture and Innovation, National Kaohsiung University of Hospitality and Tourism, 812301 No.1, Songhe Rd., Xiaogang Dist., Kaohsiung 833, Taiwan
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Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
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Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
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Aging and Disease Prevention Research Center, Fooyin University, Kaohsiung 83102, Taiwan
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Biomed Analysis Center, Fooyin University Hospital, Pingtung 92849, Taiwan
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Experimental Seafood Processing Laboratory, Costal Research and Extension Center, Mississippi State University, Pascagoula, MS 39567, USA
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Department of Food Science, Nutrition and Health Promotion, Mississippi State University, Starkville, MS 39762, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Gianfranco Alpini
Int. J. Mol. Sci. 2021, 22(10), 5273; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105273
Received: 21 April 2021 / Revised: 8 May 2021 / Accepted: 14 May 2021 / Published: 17 May 2021
(This article belongs to the Special Issue Health Benefits of Resveratrol 3.0)
Resveratrol can affect the physiology or biochemistry of offspring in the maternal–fetal animal model. However, it exhibits low bioavailability in humans and animals. Fifteen-week SD pregnant female rats were orally administered bisphenol A (BPA) and/or resveratrol butyrate ester (RBE), and the male offspring rats (n = 4–8 per group) were evaluated. The results show that RBE treatment (BPA + R30) compared with the BPA group can reduce the damage caused by BPA (p < 0.05). RBE enhanced the expression of selected genes and induced extramedullary hematopoiesis and mononuclear cell infiltration. RBE increased the abundance of S24-7 and Adlercreutzia in the intestines of the male offspring rats, as well as the concentrations of short-chain fatty acids (SCFAs) in the feces. RBE also increased the antioxidant capacity of the liver by inducing Nrf2, promoting the expression of HO-1, SOD, and CAT. It also increased the concentration of intestinal SCFAs, enhancing the barrier formed by intestinal cells, thereby preventing BPA-induced metabolic disruption in the male offspring rats, and reduced liver inflammation. This study identified a potential mechanism underlying the protective effects of RBE against the liver damage caused by BPA exposure during the peri-pregnancy period, and the influence of the gut microbiota on the gut–liver axis in the offspring. View Full-Text
Keywords: resveratrol butyrate esters (RBE); maternal/fetal animal model; bisphenol A (BPA); gut microbiota; short-chain fatty acids (SCFAs); offspring resveratrol butyrate esters (RBE); maternal/fetal animal model; bisphenol A (BPA); gut microbiota; short-chain fatty acids (SCFAs); offspring
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MDPI and ACS Style

Liao, J.-X.; Chen, Y.-W.; Shih, M.-K.; Tain, Y.-L.; Yeh, Y.-T.; Chiu, M.-H.; Chang, S.K.C.; Hou, C.-Y. Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota. Int. J. Mol. Sci. 2021, 22, 5273. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105273

AMA Style

Liao J-X, Chen Y-W, Shih M-K, Tain Y-L, Yeh Y-T, Chiu M-H, Chang SKC, Hou C-Y. Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota. International Journal of Molecular Sciences. 2021; 22(10):5273. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105273

Chicago/Turabian Style

Liao, Jin-Xian, Yu-Wei Chen, Ming-Kuei Shih, You-Lin Tain, Yao-Tsung Yeh, Min-Hsi Chiu, Sam K.C. Chang, and Chih-Yao Hou. 2021. "Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota" International Journal of Molecular Sciences 22, no. 10: 5273. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105273

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