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Review

Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species

1
Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia
2
Fidelta Ltd., Prilaz baruna Filipovica 29, 10000 Zagreb, Croatia
3
Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia
4
Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia
5
Department of Cellular Biochemistry, University Medical Center, Georg-August-University Göttingen, Humboldtallee 23, D-37073 Göttingen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Eiji Morita
Int. J. Mol. Sci. 2021, 22(10), 5274; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105274
Received: 31 March 2021 / Revised: 10 May 2021 / Accepted: 12 May 2021 / Published: 17 May 2021
Numerous viruses hijack cellular protein trafficking pathways to mediate cell entry or to rearrange membrane structures thereby promoting viral replication and antagonizing the immune response. Adaptor protein complexes (AP), which mediate protein sorting in endocytic and secretory transport pathways, are one of the conserved viral targets with many viruses possessing AP-interacting motifs. We present here different mechanisms of viral interference with AP complexes and the functional consequences that allow for efficient viral propagation and evasion of host immune defense. The ubiquity of this phenomenon is evidenced by the fact that there are representatives for AP interference in all major viral families, covered in this review. The best described examples are interactions of human immunodeficiency virus and human herpesviruses with AP complexes. Several other viruses, like Ebola, Nipah, and SARS-CoV-2, are pointed out as high priority disease-causative agents supporting the need for deeper understanding of virus-AP interplay which can be exploited in the design of novel antiviral therapies. View Full-Text
Keywords: adaptor protein complexes; protein sorting; endocytosis; herpesviruses; HIV; respiratory viruses; hemorrhagic fever viruses adaptor protein complexes; protein sorting; endocytosis; herpesviruses; HIV; respiratory viruses; hemorrhagic fever viruses
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MDPI and ACS Style

Strazic Geljic, I.; Kucan Brlic, P.; Musak, L.; Karner, D.; Ambriović-Ristov, A.; Jonjic, S.; Schu, P.; Rovis, T.L. Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species. Int. J. Mol. Sci. 2021, 22, 5274. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105274

AMA Style

Strazic Geljic I, Kucan Brlic P, Musak L, Karner D, Ambriović-Ristov A, Jonjic S, Schu P, Rovis TL. Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species. International Journal of Molecular Sciences. 2021; 22(10):5274. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105274

Chicago/Turabian Style

Strazic Geljic, Ivana, Paola Kucan Brlic, Lucija Musak, Dubravka Karner, Andreja Ambriović-Ristov, Stipan Jonjic, Peter Schu, and Tihana L. Rovis 2021. "Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species" International Journal of Molecular Sciences 22, no. 10: 5274. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105274

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