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Review

MicroRNA as a Prognostic and Diagnostic Marker in T-Cell Acute Lymphoblastic Leukemia

1
Laboratory of Genetic Diagnostics, Medical University of Lublin, 20-093 Lublin, Poland
2
Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, 20-093 Lublin, Poland
*
Author to whom correspondence should be addressed.
These authors contributed equally as a senior and supervisor author.
Academic Editor: Cristina Papayannidis
Int. J. Mol. Sci. 2021, 22(10), 5317; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105317
Received: 13 April 2021 / Revised: 12 May 2021 / Accepted: 16 May 2021 / Published: 18 May 2021
(This article belongs to the Special Issue Metabolism and Leukemia: From Biology to Therapies)
T cell acute lymphoblastic leukemia (T-ALL) is a biologically and genetically heterogeneous disease with a poor prognosis overall and several subtypes. The neoplastic transformation takes place through the accumulation of numerous genetic and epigenetic abnormalities. There are only a few prognostic factors in comparison to B cell precursor acute lymphoblastic leukemia, which is characterized by a lower variability and more homogeneous course. The microarray and next-generation sequencing (NGS) technologies exploring the coding and non-coding part of the genome allow us to reveal the complexity of the genomic and transcriptomic background of T-ALL. miRNAs are a class of non-coding RNAs that are involved in the regulation of cellular functions: cell proliferations, apoptosis, migrations, and many other processes. No miRNA has become a significant prognostic and diagnostic factor in T-ALL to date; therefore, this topic of investigation is extremely important, and T-ALL is the subject of intensive research among scientists. The altered expression of many genes in T-ALL might also be caused by wide miRNA dysregulation. The following review focuses on summarizing and characterizing the microRNAs of pediatric patients with T-ALL diagnosis and their potential future use as predictive factors. View Full-Text
Keywords: T-ALL; microRNA; T-ALL markers; diagnostic marker; predictive marker T-ALL; microRNA; T-ALL markers; diagnostic marker; predictive marker
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MDPI and ACS Style

Gębarowska, K.; Mroczek, A.; Kowalczyk, J.R.; Lejman, M. MicroRNA as a Prognostic and Diagnostic Marker in T-Cell Acute Lymphoblastic Leukemia. Int. J. Mol. Sci. 2021, 22, 5317. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105317

AMA Style

Gębarowska K, Mroczek A, Kowalczyk JR, Lejman M. MicroRNA as a Prognostic and Diagnostic Marker in T-Cell Acute Lymphoblastic Leukemia. International Journal of Molecular Sciences. 2021; 22(10):5317. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105317

Chicago/Turabian Style

Gębarowska, Katarzyna, Anna Mroczek, Jerzy R. Kowalczyk, and Monika Lejman. 2021. "MicroRNA as a Prognostic and Diagnostic Marker in T-Cell Acute Lymphoblastic Leukemia" International Journal of Molecular Sciences 22, no. 10: 5317. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105317

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