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Tumor Dormancy: Implications for Invasion and Metastasis
Review

Programmed Death-Ligand 1 as a Regulator of Tumor Progression and Metastasis

1
Department of Medicine, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, Greece
2
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
3
Department of Biology, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Aamir Ahmad
Int. J. Mol. Sci. 2021, 22(10), 5383; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105383
Received: 6 April 2021 / Revised: 18 April 2021 / Accepted: 18 May 2021 / Published: 20 May 2021
Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint has long been implicated in modeling antitumor immunity; PD-1/PD-L1 axis inhibitors exert their antitumor effects by relieving PD-L1-mediated suppression on tumor-infiltrating T lymphocytes. However, recent studies have unveiled a distinct, tumor-intrinsic, potential role for PD-L1. In this review, we focus on tumor-intrinsic PD-L1 signaling and delve into preclinical evidence linking PD-L1 protein expression with features of epithelial-to-mesenchymal transition program, cancer stemness and known oncogenic pathways. We further summarize data from studies supporting the prognostic significance of PD-L1 in different tumor types. We show that PD-L1 may indeed have oncogenic potential and act as a regulator of tumor progression and metastasis. View Full-Text
Keywords: PD-1; PD-L1; cancer; progression; metastasis PD-1; PD-L1; cancer; progression; metastasis
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MDPI and ACS Style

Vathiotis, I.A.; Gomatou, G.; Stravopodis, D.J.; Syrigos, N. Programmed Death-Ligand 1 as a Regulator of Tumor Progression and Metastasis. Int. J. Mol. Sci. 2021, 22, 5383. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105383

AMA Style

Vathiotis IA, Gomatou G, Stravopodis DJ, Syrigos N. Programmed Death-Ligand 1 as a Regulator of Tumor Progression and Metastasis. International Journal of Molecular Sciences. 2021; 22(10):5383. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105383

Chicago/Turabian Style

Vathiotis, Ioannis A., Georgia Gomatou, Dimitrios J. Stravopodis, and Nikolaos Syrigos. 2021. "Programmed Death-Ligand 1 as a Regulator of Tumor Progression and Metastasis" International Journal of Molecular Sciences 22, no. 10: 5383. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105383

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