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Article

Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice

Key Laboratory of Animal Genetics, Breeding and Reproduction Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
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Academic Editor: Grażyna Nowicka
Int. J. Mol. Sci. 2021, 22(10), 5390; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105390
Received: 22 April 2021 / Revised: 9 May 2021 / Accepted: 11 May 2021 / Published: 20 May 2021
(This article belongs to the Special Issue Obesity, Genes, and Obesity-Related Disorders)
Obesity-induced adipose tissue dysfunction and disorders of glycolipid metabolism have become a worldwide research priority. Zfp217 plays a crucial role in adipogenesis of 3T3-L1 preadipocytes, but about its functions in animal models are not yet clear. To explore the role of Zfp217 in high-fat diet (HFD)-induced obese mice, global Zfp217 heterozygous knockout (Zfp217+/−) mice were constructed. Zfp217+/− mice and Zfp217+/+ mice fed a normal chow diet (NC) did not differ significantly in weight gain, percent body fat mass, glucose tolerance, or insulin sensitivity. When challenged with HFD, Zfp217+/− mice had less weight gain than Zfp217+/+ mice. Histological observations revealed that Zfp217+/− mice fed a high-fat diet had much smaller white adipocytes in inguinal white adipose tissue (iWAT). Zfp217+/− mice had improved metabolic profiles, including improved glucose tolerance, enhanced insulin sensitivity, and increased energy expenditure compared to the Zfp217+/+ mice under HFD. We found that adipogenesis-related genes were increased and metabolic thermogenesis-related genes were decreased in the iWAT of HFD-fed Zfp217+/+ mice compared to Zfp217+/− mice. In addition, adipogenesis was markedly reduced in mouse embryonic fibroblasts (MEFs) from Zfp217-deleted mice. Together, these data indicate that Zfp217 is a regulator of energy metabolism and it is likely to provide novel insight into treatment for obesity. View Full-Text
Keywords: Zfp217; obesity; adipogenesis; glucose tolerance; insulin sensitivity; energy expenditure Zfp217; obesity; adipogenesis; glucose tolerance; insulin sensitivity; energy expenditure
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MDPI and ACS Style

Zeng, Q.; Wang, N.; Zhang, Y.; Yang, Y.; Li, S.; Zheng, R.; Chai, J.; Qiao, T.; Jiang, S. Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice. Int. J. Mol. Sci. 2021, 22, 5390. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105390

AMA Style

Zeng Q, Wang N, Zhang Y, Yang Y, Li S, Zheng R, Chai J, Qiao T, Jiang S. Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice. International Journal of Molecular Sciences. 2021; 22(10):5390. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105390

Chicago/Turabian Style

Zeng, Qianhui, Nannan Wang, Yaru Zhang, Yuxuan Yang, Shuangshuang Li, Rong Zheng, Jin Chai, Tong Qiao, and Siwen Jiang. 2021. "Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice" International Journal of Molecular Sciences 22, no. 10: 5390. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105390

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