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Review

Nanotechnology Facilitated Cultured Neuronal Network and Its Applications

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Biomanufacturing Technology, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Singapore 138668, Singapore
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Cognitive Neuroimaging Centre, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore
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Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore
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School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore
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Department of Clinical Neuroscience, Karolinska Institute, S-171 76 Stockholm, Sweden
*
Authors to whom correspondence should be addressed.
Academic Editors: Marek J. Łos and Artur Cieślar-Pobuda
Int. J. Mol. Sci. 2021, 22(11), 5552; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115552
Received: 30 March 2021 / Revised: 20 May 2021 / Accepted: 20 May 2021 / Published: 24 May 2021
(This article belongs to the Special Issue Recent Advances in Biotechnology)
The development of a biomimetic neuronal network from neural cells is a big challenge for researchers. Recent advances in nanotechnology, on the other hand, have enabled unprecedented tools and techniques for guiding and directing neural stem cell proliferation and differentiation in vitro to construct an in vivo-like neuronal network. Nanotechnology allows control over neural stem cells by means of scaffolds that guide neurons to reform synaptic networks in suitable directions in 3D architecture, surface modification/nanopatterning to decide cell fate and stimulate/record signals from neurons to find out the relationships between neuronal circuit connectivity and their pathophysiological functions. Overall, nanotechnology-mediated methods facilitate precise physiochemical controls essential to develop tools appropriate for applications in neuroscience. This review emphasizes the newest applications of nanotechnology for examining central nervous system (CNS) roles and, therefore, provides an insight into how these technologies can be tested in vitro before being used in preclinical and clinical research and their potential role in regenerative medicine and tissue engineering. View Full-Text
Keywords: nanotechnology; neuronal network; neural stem cells; nanopatterning; nanoelectrode; neuronal signal recording nanotechnology; neuronal network; neural stem cells; nanopatterning; nanoelectrode; neuronal signal recording
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MDPI and ACS Style

Singh, S.; Mishra, S.; Juha, S.; Pramanik, M.; Padmanabhan, P.; Gulyás, B. Nanotechnology Facilitated Cultured Neuronal Network and Its Applications. Int. J. Mol. Sci. 2021, 22, 5552. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115552

AMA Style

Singh S, Mishra S, Juha S, Pramanik M, Padmanabhan P, Gulyás B. Nanotechnology Facilitated Cultured Neuronal Network and Its Applications. International Journal of Molecular Sciences. 2021; 22(11):5552. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115552

Chicago/Turabian Style

Singh, Satnam, Sachin Mishra, Song Juha, Manojit Pramanik, Parasuraman Padmanabhan, and Balázs Gulyás. 2021. "Nanotechnology Facilitated Cultured Neuronal Network and Its Applications" International Journal of Molecular Sciences 22, no. 11: 5552. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115552

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