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Article

Resveratrol Attenuates the Proliferation of Prostatic Stromal Cells in Benign Prostatic Hyperplasia by Regulating Cell Cycle Progression, Apoptosis, Signaling Pathways, BPH Markers, and NF-κB Activity

Department of Food and Nutrition, Chung-Ang University, Anseong 17546, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Pavel Soucek
Int. J. Mol. Sci. 2021, 22(11), 5969; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115969
Received: 1 April 2021 / Revised: 21 May 2021 / Accepted: 25 May 2021 / Published: 31 May 2021
(This article belongs to the Special Issue Health Benefits of Resveratrol 3.0)
Resveratrol can inhibit cell proliferation and metastasis and induce apoptosis. However, the mechanisms of action through which resveratrol inhibits the abnormal proliferation of prostate stromal cells, causing prostatic hyperplasia, have not been fully elucidated. Here, we evaluated the inhibitory effects of resveratrol on cell proliferation associated with prostatic hyperplasia using WPMY-1 cells. Our results showed that resveratrol inhibited the proliferation of WPMY-1 cells via the induction of G0/G1-phase cell cycle arrest, which was caused by downregulated expression of cyclins and cyclin-dependent kinases regulated by increased p21WAF1 and p27KIP1 expression level. In addition, resveratrol treatment suppressed the phosphorylation of phosphatidylinositol 3-kinase/AKT and extracellular signal-regulated kinase 1/2. The expression levels of molecular markers affecting prostate development were also reduced by treatment with resveratrol. Finally, resveratrol attenuated the binding activity of the transcription factor nuclear factor-κB in WPMY-1 cells, and accelerated apoptotic cell death via intrinsic cascade pathway. These results indicate that resveratrol may be useful for the prevention or treatment of prostatic hyperplasia. View Full-Text
Keywords: resveratrol; benign prostatic hyperplasia; WPMY-1 cells; proliferation; cell cycle; nuclear factor-κB resveratrol; benign prostatic hyperplasia; WPMY-1 cells; proliferation; cell cycle; nuclear factor-κB
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MDPI and ACS Style

Jang, J.; Song, J.; Lee, J.; Moon, S.-K.; Moon, B. Resveratrol Attenuates the Proliferation of Prostatic Stromal Cells in Benign Prostatic Hyperplasia by Regulating Cell Cycle Progression, Apoptosis, Signaling Pathways, BPH Markers, and NF-κB Activity. Int. J. Mol. Sci. 2021, 22, 5969. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115969

AMA Style

Jang J, Song J, Lee J, Moon S-K, Moon B. Resveratrol Attenuates the Proliferation of Prostatic Stromal Cells in Benign Prostatic Hyperplasia by Regulating Cell Cycle Progression, Apoptosis, Signaling Pathways, BPH Markers, and NF-κB Activity. International Journal of Molecular Sciences. 2021; 22(11):5969. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115969

Chicago/Turabian Style

Jang, Jowon, Junhui Song, Jiyun Lee, Sung-Kwon Moon, and Bokyung Moon. 2021. "Resveratrol Attenuates the Proliferation of Prostatic Stromal Cells in Benign Prostatic Hyperplasia by Regulating Cell Cycle Progression, Apoptosis, Signaling Pathways, BPH Markers, and NF-κB Activity" International Journal of Molecular Sciences 22, no. 11: 5969. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115969

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