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Review

The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart

1
Department of Gastroenterology, Balikesir University Medical School, Cagis, Balikesir 10145, Turkey
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Department of Internal Medicine, Balikesir University Medical School, Cagis, Balikesir 10145, Turkey
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Department of Gastroenterology, Samsun Education and Research Hospital, University of Health Sciences, Ilkadim, Samsun 55090, Turkey
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Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
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Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of South Carolina, Columbia, SC 29208, USA
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Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, Italy
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Department of Endocrinology and Metabolism, Gulhane Medical School, University of Health Sciences, Ankara 06010, Turkey
*
Author to whom correspondence should be addressed.
Academic Editor: Yoshio Fujitani
Int. J. Mol. Sci. 2021, 22(12), 6627; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22126627
Received: 5 May 2021 / Revised: 17 June 2021 / Accepted: 17 June 2021 / Published: 21 June 2021
(This article belongs to the Special Issue Metabolic Syndrome: From Molecular Mechanisms to Novel Therapies)
Nonalcoholic fatty liver disease (NAFLD) is strongly associated to the features of metabolic syndrome which can progress to cirrhosis, liver failure and hepatocellular carcinoma. However, the most common cause of mortality in people with NAFLD is not liver-related but stems from atherosclerotic cardiovascular disease (CVD). The prevalence of NAFLD is on the rise, mainly as a consequence of its close association with two major worldwide epidemics, obesity and type 2 diabetes (T2D). The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression and CVD have not been completely elucidated. Human fetuin-A (alpha-2-Heremans Schmid glycoprotein), a glycoprotein produced by the liver and abundantly secreted into the circulation appears to play a role in insulin resistance, metabolic syndrome and inflammation. This review discusses the links between NAFLD and CVD by specifically focusing on fetuin-A’s function in the pathogenesis of NAFLD and atherosclerotic CVD. View Full-Text
Keywords: NAFLD; Fetuin-A; CVD NAFLD; Fetuin-A; CVD
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MDPI and ACS Style

Dogru, T.; Kirik, A.; Gurel, H.; Rizvi, A.A.; Rizzo, M.; Sonmez, A. The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart. Int. J. Mol. Sci. 2021, 22, 6627. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22126627

AMA Style

Dogru T, Kirik A, Gurel H, Rizvi AA, Rizzo M, Sonmez A. The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart. International Journal of Molecular Sciences. 2021; 22(12):6627. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22126627

Chicago/Turabian Style

Dogru, Teoman, Ali Kirik, Hasan Gurel, Ali A. Rizvi, Manfredi Rizzo, and Alper Sonmez. 2021. "The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart" International Journal of Molecular Sciences 22, no. 12: 6627. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22126627

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