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Review

Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms

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Biomedical Research Center, Qatar University, Doha 2713, Qatar
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Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, Doha 2713, Qatar
*
Authors to whom correspondence should be addressed.
Academic Editor: Francesco Caruso
Int. J. Mol. Sci. 2021, 22(13), 6703; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136703
Received: 20 May 2021 / Revised: 29 May 2021 / Accepted: 3 June 2021 / Published: 23 June 2021
(This article belongs to the Special Issue Molecular Interactions and Mechanisms of COVID-19 Inhibition)
The SARS-CoV-2 virus utilizes angiotensin converting enzyme (ACE-2) for cell entry and infection. This enzyme has important functions in the renin-angiotensin aldosterone system to preserve cardiovascular function. In addition to the heart, it is expressed in many tissues including the lung, intestines, brain, and kidney, however, its functions in these organs are mostly unknown. ACE-2 has membrane-bound and soluble forms. Its expression levels are altered in disease states and by a variety of medications. Currently, it is not clear how altered ACE-2 levels influence ACE-2 virulence and relevant complications. In addition, membrane-bound and soluble forms are thought to have different effects. Most work on this topic in the literature is on the SARS-CoV virus that has a high genetic resemblance to SARS-Co-V-2 and also uses ACE-2 enzyme to enter the cell, but with much lower affinity. More recent studies on SARS-CoV-2 are mainly clinical studies aiming at relating the effect of medications that are thought to influence ACE-2 levels, with COVID-19 outcomes for patients under these medications. This review paper aims to summarize what is known about the relationship between ACE-2 levels and SARS-CoV/SARS-CoV-2 virulence under altered ACE-2 expression states. View Full-Text
Keywords: ACE-2; SARS-CoV; COVID-19; shedding; ACE inhibitors; RAAS; angiotensin receptor blockers; ARDS ACE-2; SARS-CoV; COVID-19; shedding; ACE inhibitors; RAAS; angiotensin receptor blockers; ARDS
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MDPI and ACS Style

Yalcin, H.C.; Sukumaran, V.; Al-Ruweidi, M.K.A.A.; Shurbaji, S. Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms. Int. J. Mol. Sci. 2021, 22, 6703. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136703

AMA Style

Yalcin HC, Sukumaran V, Al-Ruweidi MKAA, Shurbaji S. Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms. International Journal of Molecular Sciences. 2021; 22(13):6703. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136703

Chicago/Turabian Style

Yalcin, Huseyin C., Vijayakumar Sukumaran, Mahmoud K.A.A. Al-Ruweidi, and Samar Shurbaji. 2021. "Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms" International Journal of Molecular Sciences 22, no. 13: 6703. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136703

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