Next Article in Journal
Neutrophils in Tumorigenesis: Missing Targets for Successful Next Generation Cancer Therapies?
Next Article in Special Issue
Immunity in Atherosclerosis: Focusing on T and B Cells
Previous Article in Journal
Evaluation of Insulin-Like Activity of Novel Zinc Metal–Organics toward Adipogenesis Signaling
Previous Article in Special Issue
ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis
Review

The Role of Mitochondrial Mutations and Chronic Inflammation in Diabetes

1
Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine, 210026 Vitebsk, Belarus
2
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia
3
Department of Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Simrol 456552, India
4
Institute of Human Morphology, 117418 Moscow, Russia
5
Federal Research Centre for Nutrition, Biotechnology and Food Safety, 109240 Moscow, Russia
6
Therapy Faculty, Pirogov Russian National Research Medical University, 117997 Moscow, Russia
7
V.A. Nasonova Institute of Rheumatology, 115522 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Giuseppe Pugliese
Int. J. Mol. Sci. 2021, 22(13), 6733; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136733
Received: 30 May 2021 / Revised: 16 June 2021 / Accepted: 19 June 2021 / Published: 23 June 2021
Diabetes mellitus and related disorders significantly contribute to morbidity and mortality worldwide. Despite the advances in the current therapeutic methods, further development of anti-diabetic therapies is necessary. Mitochondrial dysfunction is known to be implicated in diabetes development. Moreover, specific types of mitochondrial diabetes have been discovered, such as MIDD (maternally inherited diabetes and deafness) and DAD (diabetes and Deafness). Hereditary mitochondrial disorders are caused by certain mutations in the mitochondrial DNA (mtDNA), which encodes for a substantial part of mitochondrial proteins and mitochondrial tRNA necessary for mitochondrial protein synthesis. Study of mtDNA mutations is challenging because the pathogenic phenotype associated with such mutations depends on the level of its heteroplasmy (proportion of mtDNA copies carrying the mutation) and can be tissue-specific. Nevertheless, modern sequencing methods have allowed describing and characterizing a number of mtDNA mutations associated with human disorders, and the list is constantly growing. In this review, we provide a list of mtDNA mutations associated with diabetes and related disorders and discuss the mechanisms of their involvement in the pathology development. View Full-Text
Keywords: diabetes; MIDD; mitochondria; mtDNA mutations; oxidative stress diabetes; MIDD; mitochondria; mtDNA mutations; oxidative stress
Show Figures

Figure 1

MDPI and ACS Style

Dabravolski, S.A.; Orekhova, V.A.; Baig, M.S.; Bezsonov, E.E.; Starodubova, A.V.; Popkova, T.V.; Orekhov, A.N. The Role of Mitochondrial Mutations and Chronic Inflammation in Diabetes. Int. J. Mol. Sci. 2021, 22, 6733. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136733

AMA Style

Dabravolski SA, Orekhova VA, Baig MS, Bezsonov EE, Starodubova AV, Popkova TV, Orekhov AN. The Role of Mitochondrial Mutations and Chronic Inflammation in Diabetes. International Journal of Molecular Sciences. 2021; 22(13):6733. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136733

Chicago/Turabian Style

Dabravolski, Siarhei A., Varvara A. Orekhova, Mirza S. Baig, Evgeny E. Bezsonov, Antonina V. Starodubova, Tatyana V. Popkova, and Alexander N. Orekhov 2021. "The Role of Mitochondrial Mutations and Chronic Inflammation in Diabetes" International Journal of Molecular Sciences 22, no. 13: 6733. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136733

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop