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The Role of Mitochondrial Mutations and Chronic Inflammation in Diabetes

Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine, 210026 Vitebsk, Belarus
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia
Department of Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Simrol 456552, India
Institute of Human Morphology, 117418 Moscow, Russia
Federal Research Centre for Nutrition, Biotechnology and Food Safety, 109240 Moscow, Russia
Therapy Faculty, Pirogov Russian National Research Medical University, 117997 Moscow, Russia
V.A. Nasonova Institute of Rheumatology, 115522 Moscow, Russia
Author to whom correspondence should be addressed.
Academic Editor: Giuseppe Pugliese
Int. J. Mol. Sci. 2021, 22(13), 6733;
Received: 30 May 2021 / Revised: 16 June 2021 / Accepted: 19 June 2021 / Published: 23 June 2021
Diabetes mellitus and related disorders significantly contribute to morbidity and mortality worldwide. Despite the advances in the current therapeutic methods, further development of anti-diabetic therapies is necessary. Mitochondrial dysfunction is known to be implicated in diabetes development. Moreover, specific types of mitochondrial diabetes have been discovered, such as MIDD (maternally inherited diabetes and deafness) and DAD (diabetes and Deafness). Hereditary mitochondrial disorders are caused by certain mutations in the mitochondrial DNA (mtDNA), which encodes for a substantial part of mitochondrial proteins and mitochondrial tRNA necessary for mitochondrial protein synthesis. Study of mtDNA mutations is challenging because the pathogenic phenotype associated with such mutations depends on the level of its heteroplasmy (proportion of mtDNA copies carrying the mutation) and can be tissue-specific. Nevertheless, modern sequencing methods have allowed describing and characterizing a number of mtDNA mutations associated with human disorders, and the list is constantly growing. In this review, we provide a list of mtDNA mutations associated with diabetes and related disorders and discuss the mechanisms of their involvement in the pathology development. View Full-Text
Keywords: diabetes; MIDD; mitochondria; mtDNA mutations; oxidative stress diabetes; MIDD; mitochondria; mtDNA mutations; oxidative stress
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MDPI and ACS Style

Dabravolski, S.A.; Orekhova, V.A.; Baig, M.S.; Bezsonov, E.E.; Starodubova, A.V.; Popkova, T.V.; Orekhov, A.N. The Role of Mitochondrial Mutations and Chronic Inflammation in Diabetes. Int. J. Mol. Sci. 2021, 22, 6733.

AMA Style

Dabravolski SA, Orekhova VA, Baig MS, Bezsonov EE, Starodubova AV, Popkova TV, Orekhov AN. The Role of Mitochondrial Mutations and Chronic Inflammation in Diabetes. International Journal of Molecular Sciences. 2021; 22(13):6733.

Chicago/Turabian Style

Dabravolski, Siarhei A., Varvara A. Orekhova, Mirza S. Baig, Evgeny E. Bezsonov, Antonina V. Starodubova, Tatyana V. Popkova, and Alexander N. Orekhov 2021. "The Role of Mitochondrial Mutations and Chronic Inflammation in Diabetes" International Journal of Molecular Sciences 22, no. 13: 6733.

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