Next Article in Journal
Secretome Analysis of ArabidopsisTrichoderma atroviride Interaction Unveils New Roles for the Plant Glutamate:Glyoxylate Aminotransferase GGAT1 in Plant Growth Induced by the Fungus and Resistance against Botrytis cinerea
Previous Article in Journal
Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome
Previous Article in Special Issue
A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption
Review

Salivary Cytokines as Biomarkers for Oral Squamous Cell Carcinoma: A Systematic Review

1
Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy
2
Centro Universitario di Odontoiatria, University of Parma, 43125 Parma, Italy
3
Dentistry and Oral and Maxillofacial Surgery, Department of Surgical, Medical, Dental and Morphological Science with Interest in Transplant Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, 40100 Modena, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Pavel Soucek
Int. J. Mol. Sci. 2021, 22(13), 6795; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136795
Received: 1 June 2021 / Revised: 17 June 2021 / Accepted: 17 June 2021 / Published: 24 June 2021
(This article belongs to the Special Issue Human Saliva as a Source of Biomarkers for Oral Diseases)
The prognosis of patients with oral squamous carcinoma (OSCC) largely depends on the stage at diagnosis, the 5-year survival rate being approximately 30% for advanced tumors. Early diagnosis, including the detection of lesions at risk for malignant transformation, is crucial for limiting the need for extensive surgery and for improving disease-free survival. Saliva has gained popularity as a readily available source of biomarkers (including cytokines) useful for diagnosing specific oral and systemic conditions. Particularly, the close interaction between oral dysplastic/neoplastic cells and saliva makes such fluid an ideal candidate for the development of non-invasive and highly accurate diagnostic tests. The present review has been designed to answer the question: “Is there evidence to support the role of specific salivary cytokines in the diagnosis of OSCC?” We retrieved 27 observational studies satisfying the inclusion and exclusion criteria. Among the most frequent cytokines investigated as candidates for OSCC biomarkers, IL-6, IL-8, TNF-α are present at higher concentration in the saliva of OSCC patients than in healthy controls and may therefore serve as basis for the development of rapid tests for early diagnosis of oral cancer. View Full-Text
Keywords: oral cancer; oral squamous cell carcinoma; biomarkers; cytokines; oral potentially malignant disorders oral cancer; oral squamous cell carcinoma; biomarkers; cytokines; oral potentially malignant disorders
Show Figures

Figure 1

MDPI and ACS Style

Ferrari, E.; Pezzi, M.E.; Cassi, D.; Pertinhez, T.A.; Spisni, A.; Meleti, M. Salivary Cytokines as Biomarkers for Oral Squamous Cell Carcinoma: A Systematic Review. Int. J. Mol. Sci. 2021, 22, 6795. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136795

AMA Style

Ferrari E, Pezzi ME, Cassi D, Pertinhez TA, Spisni A, Meleti M. Salivary Cytokines as Biomarkers for Oral Squamous Cell Carcinoma: A Systematic Review. International Journal of Molecular Sciences. 2021; 22(13):6795. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136795

Chicago/Turabian Style

Ferrari, Elena, Margherita E. Pezzi, Diana Cassi, Thelma A. Pertinhez, Alberto Spisni, and Marco Meleti. 2021. "Salivary Cytokines as Biomarkers for Oral Squamous Cell Carcinoma: A Systematic Review" International Journal of Molecular Sciences 22, no. 13: 6795. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136795

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop