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Antiepileptic Stiripentol May Influence Bones

Department of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland
Department of Mechanics, Materials and Biomedical Engineering, Wroclaw University of Science and Technology, ul. Ignacego Łukasiewicza 7/9, 50-371 Wrocław, Poland
Department of Endocrinology, Diabetology and Internal Medicine, Tadeusz Marciniak Lower Silesia Specialist Hospital—Centre for Medical Emergency, ul. Gen. Augusta Emila Fieldorfa 2, 54-049 Wrocław, Poland
Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, wyb. Ludwika Pasteura 4, 50-367 Wrocław, Poland
Department of Maxillofacial Orthopaedics and Orthodontics, Wroclaw Medical University, ul. Krakowska 26, 50-425 Wrocław, Poland
Department of Medical Biochemistry, Wroclaw Medical University, ul. Tytusa Chałubińskiego 10, 50-368 Wrocław, Poland
Author to whom correspondence should be addressed.
Academic Editor: David Magne
Int. J. Mol. Sci. 2021, 22(13), 7162;
Received: 8 June 2021 / Revised: 27 June 2021 / Accepted: 30 June 2021 / Published: 2 July 2021
(This article belongs to the Special Issue Secondary Osteoporosis in Adults 2.0)
Bone structure abnormalities are increasingly observed in patients chronically treated with antiepileptic drugs (AEDs). The majority of the available data concern older conventional AEDs, while the amount of information regarding newer AEDs, including stiripentol, is limited. The aim of the study was to assess the effect of stiripentol on bones. For 24 weeks, male Wistar rats, received 0.9% sodium chloride (control group) or stiripentol (200 mg/kg/day) (STP group). In the 16th week of the study, we detected lower serum PINP levels in the STP group compared to the control group. In the 24th week, a statistically significant lower 1,25-dihydroxyvitamin D3 level, higher inorganic phosphate level and higher neutrophil gelatinase-associated lipocalin (NGAL) levels in serum were found in the STP group compared to the control. Micro X-ray computed tomography of the tibias demonstrated lower bone volume fraction, lower trabecular thickness, higher trabecular pattern factor and a higher structure model index in the stiripentol group. Considering the results of this experiment on rats which suggests that long-term administration of stiripentol may impair the cancellous bone microarchitecture, further prospective human studies seem to be justified. However, monitoring plasma vitamin D, calcium, inorganic phosphate and kidney function in patients on long-term stiripentol therapy may be suggested. View Full-Text
Keywords: antiepileptic drug; bone; computed tomography; stiripentol; vitamin D antiepileptic drug; bone; computed tomography; stiripentol; vitamin D
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MDPI and ACS Style

Matuszewska, A.; Nowak, B.; Nikodem, A.; Merwid-Ląd, A.; Wiatrak, B.; Tomkalski, T.; Jędrzejuk, D.; Szeląg, E.; Sozański, T.; Danielewski, M.; Jawień, P.; Ceremuga, I.; Szandruk-Bender, M.; Bolanowski, M.; Filipiak, J.; Szeląg, A. Antiepileptic Stiripentol May Influence Bones. Int. J. Mol. Sci. 2021, 22, 7162.

AMA Style

Matuszewska A, Nowak B, Nikodem A, Merwid-Ląd A, Wiatrak B, Tomkalski T, Jędrzejuk D, Szeląg E, Sozański T, Danielewski M, Jawień P, Ceremuga I, Szandruk-Bender M, Bolanowski M, Filipiak J, Szeląg A. Antiepileptic Stiripentol May Influence Bones. International Journal of Molecular Sciences. 2021; 22(13):7162.

Chicago/Turabian Style

Matuszewska, Agnieszka, Beata Nowak, Anna Nikodem, Anna Merwid-Ląd, Benita Wiatrak, Tomasz Tomkalski, Diana Jędrzejuk, Ewa Szeląg, Tomasz Sozański, Maciej Danielewski, Paulina Jawień, Ireneusz Ceremuga, Marta Szandruk-Bender, Marek Bolanowski, Jarosław Filipiak, and Adam Szeląg. 2021. "Antiepileptic Stiripentol May Influence Bones" International Journal of Molecular Sciences 22, no. 13: 7162.

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