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Article

Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis

by 1,2, 2,3, 3, 2,3,4, 2,3,5,6,7, 8,9, 8,9,10,11,12,13, 8,9,10 and 1,2,5,9,10,14,15,*
1
Centre for Addiction and Mental Health, Translational Addiction Research Laboratory, University of Toronto, 33 Ursula Franklin Street, Toronto, ON M5S 2S1, Canada
2
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada
3
Centre for Addiction and Mental Health, Institute for Mental Health Policy Research, Toronto, ON M6J 1H4, Canada
4
Controlled Substances and Cannabis Directorate, Health Canada, Ottawa, ON K1A 0K9, Canada
5
Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON M6J 1H4, Canada
6
Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada
7
Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON M5T 3M6, Canada
8
Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON M5T 1R8, Canada
9
Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada
10
Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada
11
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada
12
T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA
13
Broad Institute, Cambridge, MA 02142, USA
14
Acute Care Program, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada
15
Department of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Rosaria Meccariello
Int. J. Mol. Sci. 2021, 22(14), 7388; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147388
Received: 3 June 2021 / Revised: 5 July 2021 / Accepted: 6 July 2021 / Published: 9 July 2021
As many jurisdictions consider relaxing cannabis legislation and usage is increasing in North America and other parts of the world, there is a need to explore the possible genetic differences underlying the subjective effects of cannabis. This pilot study investigated specific genetic variations within the cannabinoid receptor 1 (CNR1) gene for association with the subjective effects of smoked cannabis. Data were obtained from a double-blinded, placebo-controlled clinical trial studying the impact of cannabis intoxication on driving performance. Participants randomized to the active cannabis group who consented to secondary genetic analysis (n = 52) were genotyped at the CNR1 rs1049353 and rs2023239 polymorphic areas. Maximum value and area under the curve (AUC) analyses were performed on subjective measures data. Analysis of subjective effects by genotype uncovered a global trend towards greater subjective effects for rs1049353 T-allele- and rs2023239 C-allele-carrying subjects. However, significant differences attributed to allelic identity were only documented for a subset of subjective effects. Our findings suggest that rs1049353 and rs2023239 minor allele carriers experience augmented subjective effects during acute cannabis intoxication. View Full-Text
Keywords: cannabis; Δ9-tetrahydrocannabinol; subjective effects; CNR1 gene cannabis; Δ9-tetrahydrocannabinol; subjective effects; CNR1 gene
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MDPI and ACS Style

Murphy, T.; Matheson, J.; Mann, R.E.; Brands, B.; Wickens, C.M.; Tiwari, A.K.; Zai, C.C.; Kennedy, J.; Le Foll, B. Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis. Int. J. Mol. Sci. 2021, 22, 7388. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147388

AMA Style

Murphy T, Matheson J, Mann RE, Brands B, Wickens CM, Tiwari AK, Zai CC, Kennedy J, Le Foll B. Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis. International Journal of Molecular Sciences. 2021; 22(14):7388. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147388

Chicago/Turabian Style

Murphy, Thomas, Justin Matheson, Robert E. Mann, Bruna Brands, Christine M. Wickens, Arun K. Tiwari, Clement C. Zai, James Kennedy, and Bernard Le Foll. 2021. "Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis" International Journal of Molecular Sciences 22, no. 14: 7388. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147388

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