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Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions

1
Center of Medical Innovation and Translational Research, Department of Medical Data Science, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, Japan
2
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
3
Department of Clinical and Molecular Medicine, University of Rome “Sapienza”, Santo Andrea Hospital, via di Grottarossa, 1035-00189 Rome, Italy
4
Kyowa-kai Medical Corporation, Osaka 565-0871, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Sabrina Battista
Int. J. Mol. Sci. 2021, 22(14), 7544; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147544
Received: 5 June 2021 / Revised: 8 July 2021 / Accepted: 9 July 2021 / Published: 14 July 2021
(This article belongs to the Special Issue Diet and Metabolism: Molecular Mechanisms of Health and Disease)
The recent advances in deciphering the human genome allow us to understand and evaluate the mechanisms of human genome age-associated transformations, which are largely unclear. Genome sequencing techniques assure comprehensive mapping of human genetics; however, understanding of gene functional interactions, specifically of time/age-dependent modifications, remain challenging. The age of the genome is defined by the sum of individual (inherited) and acquired genomic traits, based on internal and external factors that impact ontogenesis from the moment of egg fertilization and embryonic development. The biological part of genomic age opens a new perspective for intervention. The discovery of single cell-based mechanisms for genetic change indicates the possibility of influencing aging and associated disease burden, as well as metabolism. Cell populations with transformed genetic background were shown to serve as the origin of common diseases during extended life expectancy (superaging). Consequently, age-related cell transformation leads to cancer and cell degeneration (senescence). This article aims to describe current advances in the genomic mechanisms of senescence and its role in the spatiotemporal spread of epithelial clones and cell evolution. View Full-Text
Keywords: genome; aging; cell transformation; senescence; single cell analysis; metabolism genome; aging; cell transformation; senescence; single cell analysis; metabolism
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MDPI and ACS Style

Kitakaze, M.; Chijimatsu, R.; Vecchione, A.; Kitagawa, T.; Doki, Y.; Eguchi, H.; Ishii, H. Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions. Int. J. Mol. Sci. 2021, 22, 7544. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147544

AMA Style

Kitakaze M, Chijimatsu R, Vecchione A, Kitagawa T, Doki Y, Eguchi H, Ishii H. Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions. International Journal of Molecular Sciences. 2021; 22(14):7544. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147544

Chicago/Turabian Style

Kitakaze, Masatoshi, Ryota Chijimatsu, Andrea Vecchione, Toru Kitagawa, Yuichiro Doki, Hidetoshi Eguchi, and Hideshi Ishii. 2021. "Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions" International Journal of Molecular Sciences 22, no. 14: 7544. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147544

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