Next Article in Journal
Trop2 Expression in Extramammary Paget’s Disease and Normal Skin
Next Article in Special Issue
Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes
Previous Article in Journal
Analysis of the Structural Mechanism of ATP Inhibition at the AAA1 Subunit of Cytoplasmic Dynein-1 Using a Chemical “Toolkit”
Due to scheduled maintenance work on our core network, there may be short service disruptions on this website between 16:00 and 16:30 CEST on September 25th.
Article

Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating

1
Department of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, Poland
2
Centre of Polymer and Carbon Materials of the Polish Academy of Sciences, 34 Marii Skłodowskiej-Curie St., 41-819 Zabrze, Poland
3
Department of Biomechatronics, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, Poland
4
Materials Research Laboratory, Faculty of Mechanical Engineering, Silesian University of Technology, 18A Konarskiego St., 44-100 Gliwice, Poland
5
Department of Urology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, 13-15 3 Maja St., 41-800 Zabrze, Poland
6
Nanotechnology Centre, CEET, VŠB-Technical University of Ostrava, 17. Listopadu 15/2172, 708 00 Ostrava-Poruba, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editors: Ayae Sugawara-Narutaki and Marek J. Łos
Int. J. Mol. Sci. 2021, 22(14), 7705; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147705
Received: 14 May 2021 / Revised: 13 July 2021 / Accepted: 15 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue Biotechnology-Recent Advances)
Despite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80–90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation on the stent surface, which may favor the development of urinary tract infections or the formation of encrustation, as well as stent fragmentation, complicating its subsequent removal. In this work, the effect of the polymeric coating containing the active substance-papaverine hydrochloride on the functional properties of ureteral stents significant for clinical practice were assessed. Methods: The most commonly clinically used polyurethane ureteral Double-J stent was selected for the study. Using the dip-coating method, the surface of the stent was coated with a poly(D,L-lactide-glycolide) (PLGA) coating containing the papaverine hydrochloride (PAP). In particular, strength properties, retention strength of the stent ends, dynamic frictional force, and the fluoroscopic visibility of the stent during X-ray imaging were determined. Results: The analysis of the test results indicates the usefulness of a biodegradable polymer coating containing the active substance for the modification of the surface of polyurethane ureteral stents. The stents coated with PLGA+PAP coating compared to polyurethane stents are characterized by more favorable strength properties, the smaller value of the dynamic frictional force, without reducing the fluoroscopic visibility. View Full-Text
Keywords: ureteral stent; PLGA with papaverine hydrochloride coatings; retention strength; break strength; dynamic frictional force; radiopacity ureteral stent; PLGA with papaverine hydrochloride coatings; retention strength; break strength; dynamic frictional force; radiopacity
Show Figures

Figure 1

MDPI and ACS Style

Antonowicz, M.; Szewczenko, J.; Jaworska, J.; Jelonek, K.; Joszko, K.; Gzik-Zroska, B.; Nuckowski, P.M.; Bryniarski, P.; Paszenda, Z.; Nakonieczny, D.S.; Barabaszová, K.Č.; Kasperczyk, J. Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating. Int. J. Mol. Sci. 2021, 22, 7705. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147705

AMA Style

Antonowicz M, Szewczenko J, Jaworska J, Jelonek K, Joszko K, Gzik-Zroska B, Nuckowski PM, Bryniarski P, Paszenda Z, Nakonieczny DS, Barabaszová KČ, Kasperczyk J. Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating. International Journal of Molecular Sciences. 2021; 22(14):7705. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147705

Chicago/Turabian Style

Antonowicz, Magdalena, Janusz Szewczenko, Joanna Jaworska, Katarzyna Jelonek, Kamil Joszko, Bożena Gzik-Zroska, Paweł M. Nuckowski, Piotr Bryniarski, Zbigniew Paszenda, Damian S. Nakonieczny, Karla Č. Barabaszová, and Janusz Kasperczyk. 2021. "Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating" International Journal of Molecular Sciences 22, no. 14: 7705. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147705

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop