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Article

Trop2 Expression in Extramammary Paget’s Disease and Normal Skin

1
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
2
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Philip W. Wertz
Int. J. Mol. Sci. 2021, 22(14), 7706; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147706
Received: 22 June 2021 / Revised: 11 July 2021 / Accepted: 17 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue Barrier Function of Skin and Oral Mucosa)
Extramammary Paget’s disease (EMPD) is a rare skin cancer arising in the apocrine gland-rich areas. Most EMPD tumors are dormant, but metastatic lesions are associated with poor outcomes owing to the lack of effective systemic therapies. Trophoblast cell surface antigen 2 (Trop2), a surface glycoprotein, has drawn attention as a potential therapeutic target for solid tumors. Sacituzumab govitecan, an antibody–drug conjugate of Trop2, has recently entered clinical use for the treatment of various solid cancers. However, little is known about the role of Trop2 in EMPD. In this study, we immunohistochemically examined Trop2 expression in 116 EMPD tissue samples and 10 normal skin tissues. In normal skin, Trop2 was expressed in the epidermal keratinocytes, inner root sheaths, and infundibulum/isthmus epithelium of hair follicles, eccrine/apocrine glands, and sebaceous glands. Most EMPD tissues exhibited homogeneous and strong Trop2 expression, and high Trop2 expression was significantly associated with worse disease-free survival (p = 0.0343). These results suggest the potential use of Trop2-targeted therapy for EMPD and improve our understanding of the skin-related adverse effects of current Trop2-targeted therapies such as sacituzumab govitecan. View Full-Text
Keywords: trophoblast cell surface antigen 2 (Trop2); extramammary Paget’s disease; sacituzumab govitecan; targeted therapy trophoblast cell surface antigen 2 (Trop2); extramammary Paget’s disease; sacituzumab govitecan; targeted therapy
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MDPI and ACS Style

Ito, T.; Tanegashima, K.; Tanaka, Y.; Hashimoto, H.; Murata, M.; Oda, Y.; Kaku-Ito, Y. Trop2 Expression in Extramammary Paget’s Disease and Normal Skin. Int. J. Mol. Sci. 2021, 22, 7706. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147706

AMA Style

Ito T, Tanegashima K, Tanaka Y, Hashimoto H, Murata M, Oda Y, Kaku-Ito Y. Trop2 Expression in Extramammary Paget’s Disease and Normal Skin. International Journal of Molecular Sciences. 2021; 22(14):7706. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147706

Chicago/Turabian Style

Ito, Takamichi, Keiko Tanegashima, Yuka Tanaka, Hiroki Hashimoto, Maho Murata, Yoshinao Oda, and Yumiko Kaku-Ito. 2021. "Trop2 Expression in Extramammary Paget’s Disease and Normal Skin" International Journal of Molecular Sciences 22, no. 14: 7706. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147706

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