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Review

Extracellular Inorganic Phosphate-Induced Release of Reactive Oxygen Species: Roles in Physiological Processes and Disease Development

1
Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, RJ, Brazil
2
Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, RJ, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editors: Fabio Vescini, Andrea Palermo, Luigi Gennari, Alberto Falchetti and Iacopo Chiodini
Int. J. Mol. Sci. 2021, 22(15), 7768; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22157768
Received: 14 June 2021 / Revised: 8 July 2021 / Accepted: 19 July 2021 / Published: 21 July 2021
(This article belongs to the Special Issue Phosphate-Related Disorders: From Physiology to Diseases)
Inorganic phosphate (Pi) is an essential nutrient for living organisms and is maintained in equilibrium in the range of 0.8–1.4 mM Pi. Pi is a source of organic constituents for DNA, RNA, and phospholipids and is essential for ATP formation mainly through energy metabolism or cellular signalling modulators. In mitochondria isolated from the brain, liver, and heart, Pi has been shown to induce mitochondrial reactive oxygen species (ROS) release. Therefore, the purpose of this review article was to gather relevant experimental records of the production of Pi-induced reactive species, mainly ROS, to examine their essential roles in physiological processes, such as the development of bone and cartilage and the development of diseases, such as cardiovascular disease, diabetes, muscle atrophy, and male reproductive system impairment. Interestingly, in the presence of different antioxidants or inhibitors of cytoplasmic and mitochondrial Pi transporters, Pi-induced ROS production can be reversed and may be a possible pharmacological target. View Full-Text
Keywords: inorganic phosphate; hyperphosphataemia; reactive oxygen species inorganic phosphate; hyperphosphataemia; reactive oxygen species
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MDPI and ACS Style

Lacerda-Abreu, M.A.; Meyer-Fernandes, J.R. Extracellular Inorganic Phosphate-Induced Release of Reactive Oxygen Species: Roles in Physiological Processes and Disease Development. Int. J. Mol. Sci. 2021, 22, 7768. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22157768

AMA Style

Lacerda-Abreu MA, Meyer-Fernandes JR. Extracellular Inorganic Phosphate-Induced Release of Reactive Oxygen Species: Roles in Physiological Processes and Disease Development. International Journal of Molecular Sciences. 2021; 22(15):7768. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22157768

Chicago/Turabian Style

Lacerda-Abreu, Marco A., and José R. Meyer-Fernandes 2021. "Extracellular Inorganic Phosphate-Induced Release of Reactive Oxygen Species: Roles in Physiological Processes and Disease Development" International Journal of Molecular Sciences 22, no. 15: 7768. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22157768

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