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Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis

1
Department of Life Sciences and Systems Biology (DBIOS), University of Torino, 10123 Turin, Italy
2
Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, 10043 Turin, Italy
*
Author to whom correspondence should be addressed.
Current Address: CMP3VdA, Istituto Italiano di Tecnologia (IIT), 11100 Aosta, Italy.
Academic Editors: Luca Bonfanti and Sebastien Couillard-Despres
Int. J. Mol. Sci. 2021, 22(15), 7984; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22157984
Received: 30 June 2021 / Revised: 19 July 2021 / Accepted: 21 July 2021 / Published: 26 July 2021
(This article belongs to the Special Issue Neuron and Brain Maturation)
Steroid hormones represent an amazing class of molecules that play pleiotropic roles in vertebrates. In mammals, during postnatal development, sex steroids significantly influence the organization of sexually dimorphic neural circuits underlying behaviors critical for survival, such as the reproductive one. During the last decades, multiple studies have shown that many cortical and subcortical brain regions undergo sex steroid-dependent structural organization around puberty, a critical stage of life characterized by high sensitivity to external stimuli and a profound structural and functional remodeling of the organism. Here, we first give an overview of current data on how sex steroids shape the peripubertal brain by regulating neuroplasticity mechanisms. Then, we focus on adult neurogenesis, a striking form of persistent structural plasticity involved in the control of social behaviors and regulated by a fine-tuned integration of external and internal cues. We discuss recent data supporting that the sex steroid-dependent peripubertal organization of neural circuits involves a sexually dimorphic set-up of adult neurogenesis that in turn could be relevant for sex-specific reproductive behaviors. View Full-Text
Keywords: puberty; gonadal hormones; adult neurogenesis; sexual dimorphism; pheromones puberty; gonadal hormones; adult neurogenesis; sexual dimorphism; pheromones
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MDPI and ACS Style

Trova, S.; Bovetti, S.; Bonzano, S.; De Marchis, S.; Peretto, P. Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis. Int. J. Mol. Sci. 2021, 22, 7984. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22157984

AMA Style

Trova S, Bovetti S, Bonzano S, De Marchis S, Peretto P. Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis. International Journal of Molecular Sciences. 2021; 22(15):7984. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22157984

Chicago/Turabian Style

Trova, Sara, Serena Bovetti, Sara Bonzano, Silvia De Marchis, and Paolo Peretto. 2021. "Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis" International Journal of Molecular Sciences 22, no. 15: 7984. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22157984

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