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Article

Copresence of High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon

1
College of Medicine, QU Health, Qatar University, Doha 2713, Qatar
2
Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha 2713, Qatar
3
Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut 1107, Lebanon
4
Segal Cancer Center/Lady Davis Institute for Medical Research, JGH/McGill University, Montreal, QC H3A 0G4, Canada
5
Oncology Department, Faculty of Medicine, McGill University, Montreal, QC H3A 0G4, Canada
6
Biomedical Research Centre, QU Health, Qatar University, Doha 2713, Qatar
*
Authors to whom correspondence should be addressed.
Academic Editors: Hidekazu Suzuki, James K. Bashkin and Luis Vicente López-Llorca
Int. J. Mol. Sci. 2021, 22(15), 8118; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158118
Received: 3 May 2021 / Revised: 14 June 2021 / Accepted: 28 June 2021 / Published: 29 July 2021
(This article belongs to the Special Issue Host-Microbe Interaction 3.0)
Colorectal cancer (CRC) is the third most common cause of cancer-related deaths worldwide. Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV) have been reported to be present in different types of human cancers, including CRCs, where they can play a key role in the onset and/or progression of these cancers. Thus, we herein explored the prevalence of high-risk HPVs and EBV in a cohort of 94 CRC tissue samples and 13 colorectal normal tissues from the Lebanese population using polymerase chain reaction, immunohistochemistry, and tissue microarray methodologies. We found that high-risk HPVs are present in 64%, while EBV is present in 29% of our CRC samples. Additionally, our data showed that high-risk HPV types (16, 18, 35, 58, 51, 45, 52, 31, and 33) are the most frequent in CRC in the Lebanese cohort, respectively. Our data point out that HPVs and EBV are copresent in 28% of the samples. Thus, this study clearly suggests that high-risk HPVs and EBV are present/copresent in CRCs, where they could play an important role in colorectal carcinogenesis. Nevertheless, further investigations using a larger cohort are needed to elucidate the possible cooperation between these oncoviruses in the development of CRC. View Full-Text
Keywords: Epstein–Barr virus; human papillomavirus; colorectal cancer; tumor grade; Lebanon Epstein–Barr virus; human papillomavirus; colorectal cancer; tumor grade; Lebanon
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MDPI and ACS Style

Nagi, K.; Gupta, I.; Jurdi, N.; Yasmeen, A.; Vranic, S.; Batist, G.; Moustafa, A.-E.A. Copresence of High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon. Int. J. Mol. Sci. 2021, 22, 8118. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158118

AMA Style

Nagi K, Gupta I, Jurdi N, Yasmeen A, Vranic S, Batist G, Moustafa A-EA. Copresence of High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon. International Journal of Molecular Sciences. 2021; 22(15):8118. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158118

Chicago/Turabian Style

Nagi, Karim, Ishita Gupta, Nawaf Jurdi, Amber Yasmeen, Semir Vranic, Gerald Batist, and Ala-Eddin A. Moustafa 2021. "Copresence of High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon" International Journal of Molecular Sciences 22, no. 15: 8118. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158118

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