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Exercise Pills for Drug Addiction: Forced Moderate Endurance Exercise Inhibits Methamphetamine-Induced Hyperactivity through the Striatal Glutamatergic Signaling Pathway in Male Sprague Dawley Rats

College of Pharmacy, Keimyung University, 1095 Dalgubeoldaero, Dalseo-gu, Daegu 42601, Korea
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Author to whom correspondence should be addressed.
Academic Editor: Jin-Ho Koh
Int. J. Mol. Sci. 2021, 22(15), 8203; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158203
Received: 4 June 2021 / Revised: 26 July 2021 / Accepted: 28 July 2021 / Published: 30 July 2021
(This article belongs to the Special Issue Molecular and Cellular Exercise Physiology in Metabolism)
Physical exercise reduces the extent, duration, and frequency of drug use in drug addicts during the drug initiation phase, as well as during prolonged addiction, withdrawal, and recurrence. However, information about exercise-induced neurobiological changes is limited. This study aimed to investigate the effects of forced moderate endurance exercise training on methamphetamine (METH)-induced behavior and the associated neurobiological changes. Male Sprague Dawley rats were subjected to the administration of METH (1 mg/kg/day, i.p.) and/or forced moderate endurance exercise (treadmill running, 21 m/min, 60 min/day) for 2 weeks. Over the two weeks, endurance exercise training significantly reduced METH-induced hyperactivity. METH and/or exercise treatment increased striatal dopamine (DA) levels, decreased p(Thr308)-Akt expression, and increased p(Tyr216)-GSK-3β expression. However, the phosphorylation levels of Ser9-GSK-3β were significantly increased in the exercise group. METH administration significantly increased the expression of NMDAr1, CaMKK2, MAPKs, and PP1 in the striatum, and exercise treatment significantly decreased the expression of these molecules. Therefore, it is apparent that endurance exercise inhibited the METH-induced hyperactivity due to the decrease in GSK-3β activation by the regulation of the striatal glutamate signaling pathway. View Full-Text
Keywords: methamphetamine; drug abuse; forced endurance exercise; hyperactivity; GSK-3β; glutamatergic signaling pathway methamphetamine; drug abuse; forced endurance exercise; hyperactivity; GSK-3β; glutamatergic signaling pathway
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MDPI and ACS Style

Jung, S.; Kim, Y.; Kim, M.; Seo, M.; Kim, S.; Kim, S.; Lee, S. Exercise Pills for Drug Addiction: Forced Moderate Endurance Exercise Inhibits Methamphetamine-Induced Hyperactivity through the Striatal Glutamatergic Signaling Pathway in Male Sprague Dawley Rats. Int. J. Mol. Sci. 2021, 22, 8203. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158203

AMA Style

Jung S, Kim Y, Kim M, Seo M, Kim S, Kim S, Lee S. Exercise Pills for Drug Addiction: Forced Moderate Endurance Exercise Inhibits Methamphetamine-Induced Hyperactivity through the Striatal Glutamatergic Signaling Pathway in Male Sprague Dawley Rats. International Journal of Molecular Sciences. 2021; 22(15):8203. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158203

Chicago/Turabian Style

Jung, Suryun, Youjeong Kim, Mingyu Kim, Minjae Seo, Suji Kim, Seungju Kim, and Sooyeun Lee. 2021. "Exercise Pills for Drug Addiction: Forced Moderate Endurance Exercise Inhibits Methamphetamine-Induced Hyperactivity through the Striatal Glutamatergic Signaling Pathway in Male Sprague Dawley Rats" International Journal of Molecular Sciences 22, no. 15: 8203. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158203

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