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Article

Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells

1
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
2
National Institute of Gastroenterology “S. de Bellis”, Institute of Research, 70013 Castellana Grotte, Italy
3
Unit of Lecce, Institute of Sciences of Food Production C.N.R., 73100 Lecce, Italy
*
Authors to whom correspondence should be addressed.
These authors equally contributed to the paper.
Academic Editor: Christopher W Cutler
Int. J. Mol. Sci. 2021, 22(15), 8349; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158349
Received: 12 July 2021 / Revised: 30 July 2021 / Accepted: 30 July 2021 / Published: 3 August 2021
(This article belongs to the Special Issue Role of Dendritic Cells in Inflammation 2.0)
Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal tissues and regulate the immune response by secreting chemokines and cytokines. Inflammatory bowel diseases (IBDs) are characterized by a leaky intestinal barrier and the consequent translocation of bacterial lipopolysaccharide (LPS) to the basolateral side. This results in DCs activation, but the response of pDCs is still poorly characterized. In the present study, we compared mDCs and pDCs responses to LPS administration. We present a broad panel of DCs secreted factors, including cytokines, chemokines, and growth factors. Our recent studies demonstrated the anti-inflammatory effects of quercetin administration, but to date, there is no evidence about quercetin’s effects on pDCs. The results of the present study demonstrate that pDCs can respond to LPS and that quercetin exposure modulates soluble factors release through the same molecular pathway used by mDCs (Slpi, Hmox1, and AP-1). View Full-Text
Keywords: quercetin; dendritic cells; plasmacytoid; cytokines; slpi quercetin; dendritic cells; plasmacytoid; cytokines; slpi
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MDPI and ACS Style

Verna, G.; Liso, M.; Cavalcanti, E.; Bianco, G.; Di Sarno, V.; Santino, A.; Campiglia, P.; Chieppa, M. Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells. Int. J. Mol. Sci. 2021, 22, 8349. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158349

AMA Style

Verna G, Liso M, Cavalcanti E, Bianco G, Di Sarno V, Santino A, Campiglia P, Chieppa M. Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells. International Journal of Molecular Sciences. 2021; 22(15):8349. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158349

Chicago/Turabian Style

Verna, Giulio, Marina Liso, Elisabetta Cavalcanti, Giusy Bianco, Veronica Di Sarno, Angelo Santino, Pietro Campiglia, and Marcello Chieppa. 2021. "Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells" International Journal of Molecular Sciences 22, no. 15: 8349. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158349

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