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Immunity in Atherosclerosis: Focusing on T and B Cells

Institute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia
Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, 125315 Moscow, Russia
V.A. Nasonova Institute of Rheumatology, 34A Kashirskoye Shosse, 115522 Moscow, Russia
Federal Research Centre for Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Passage, 109240 Moscow, Russia
Medical Faculty, Pirogov Russian National Research Medical University, 1 Ostrovitianov Street, 117997 Moscow, Russia
Authors to whom correspondence should be addressed.
Academic Editor: Babak Baban
Int. J. Mol. Sci. 2021, 22(16), 8379;
Received: 16 July 2021 / Revised: 27 July 2021 / Accepted: 30 July 2021 / Published: 4 August 2021
Atherosclerosis is the major cause of the development of cardiovascular disease, which, in turn, is one of the leading causes of mortality worldwide. From the point of view of pathogenesis, atherosclerosis is an extremely complex disease. A huge variety of processes, such as violation of mitophagy, oxidative stress, damage to the endothelium, and others, are involved in atherogenesis; however, the main components of atherogenesis are considered to be inflammation and alterations of lipid metabolism. In this review, we want to focus on inflammation, and more specifically on the cellular elements of adaptive immunity, T and B cells. It is known that various T cells are widely represented directly in atherosclerotic plaques, while B cells can be found, for example, in the adventitia layer. Of course, such widespread and well-studied cells have attracted attention as potential therapeutic targets for the treatment of atherosclerosis. Various approaches have been developed and tested for their efficacy. View Full-Text
Keywords: atherosclerosis; CVD; immunity; T cells; B cells atherosclerosis; CVD; immunity; T cells; B cells
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MDPI and ACS Style

Poznyak, A.V.; Bezsonov, E.E.; Popkova, T.V.; Starodubova, A.V.; Orekhov, A.N. Immunity in Atherosclerosis: Focusing on T and B Cells. Int. J. Mol. Sci. 2021, 22, 8379.

AMA Style

Poznyak AV, Bezsonov EE, Popkova TV, Starodubova AV, Orekhov AN. Immunity in Atherosclerosis: Focusing on T and B Cells. International Journal of Molecular Sciences. 2021; 22(16):8379.

Chicago/Turabian Style

Poznyak, Anastasia V., Evgeny E. Bezsonov, Tatyana V. Popkova, Antonina V. Starodubova, and Alexander N. Orekhov 2021. "Immunity in Atherosclerosis: Focusing on T and B Cells" International Journal of Molecular Sciences 22, no. 16: 8379.

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