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Structural and Biochemical Features of Human Serum Albumin Essential for Eukaryotic Cell Culture

Protein Production Facility, Shared Resource Center, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
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Academic Editor: Alessandra Di Masi
Int. J. Mol. Sci. 2021, 22(16), 8411; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168411
Received: 30 June 2021 / Revised: 30 July 2021 / Accepted: 4 August 2021 / Published: 5 August 2021
Serum albumin physically interacts with fatty acids, small molecules, metal ions, and several other proteins. Binding with a plethora of bioactive substances makes it a critical transport molecule. Albumin also scavenges the reactive oxygen species that are harmful to cell survival. These properties make albumin an excellent choice to promote cell growth and maintain a variety of eukaryotic cells under in vitro culture environment. Furthermore, purified recombinant human serum albumin is mostly free from impurities and modifications, providing a perfect choice as an additive in cell and tissue culture media while avoiding any regulatory constraints. This review discusses key features of human serum albumin implicated in cell growth and survival under in vitro conditions. View Full-Text
Keywords: human serum albumin; cell culture; ligand binding human serum albumin; cell culture; ligand binding
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MDPI and ACS Style

Mishra, V.; Heath, R.J. Structural and Biochemical Features of Human Serum Albumin Essential for Eukaryotic Cell Culture. Int. J. Mol. Sci. 2021, 22, 8411. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168411

AMA Style

Mishra V, Heath RJ. Structural and Biochemical Features of Human Serum Albumin Essential for Eukaryotic Cell Culture. International Journal of Molecular Sciences. 2021; 22(16):8411. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168411

Chicago/Turabian Style

Mishra, Vibhor, and Richard J. Heath 2021. "Structural and Biochemical Features of Human Serum Albumin Essential for Eukaryotic Cell Culture" International Journal of Molecular Sciences 22, no. 16: 8411. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168411

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