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The Role of Monocytes and Macrophages in Homeostasis and Disease and Novel Avenues for Putative Treatments
Review

Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis

by 1, 2,* and 1,2,*
1
National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning 530021, China
2
College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing 100044, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Malgorzata Kloc and Jacek Z Kubiak
Int. J. Mol. Sci. 2021, 22(16), 8470; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168470
Received: 13 July 2021 / Revised: 30 July 2021 / Accepted: 2 August 2021 / Published: 6 August 2021
(This article belongs to the Special Issue Human and Animal Monocytes and Macrophages in Homeostasis and Disease)
Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and mortality is high-ranking among tumors worldwide. The initiation and progression of CRC is a complex process involving genetic alterations in cancer cells and multiple factors from the surrounding tumor cell microenvironment. As accumulating evidence has shown, tumor-associated macrophages (TAMs)—as abundant and active infiltrated inflammatory cells in the tumor microenvironment (TME)—play a crucial role in CRC. This review focuses on the different mechanisms of TAM in CRC, including switching of phenotypical subtypes; promoting tumor proliferation, invasion, and migration; facilitating angiogenesis; mediating immunosuppression; regulating metabolism; and interacting with the microbiota. Although controversy remains in clinical evidence regarding the role of TAMs in CRC, clarifying their significance in therapy and the prognosis of CRC may shed new light on the optimization of TAM-centered approaches in clinical care. View Full-Text
Keywords: colorectal cancer; tumor microenvironment (TME); macrophage; polarization; therapy; prognosis colorectal cancer; tumor microenvironment (TME); macrophage; polarization; therapy; prognosis
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MDPI and ACS Style

Wang, H.; Tian, T.; Zhang, J. Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis. Int. J. Mol. Sci. 2021, 22, 8470. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168470

AMA Style

Wang H, Tian T, Zhang J. Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis. International Journal of Molecular Sciences. 2021; 22(16):8470. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168470

Chicago/Turabian Style

Wang, Hui, Tian Tian, and Jinhua Zhang. 2021. "Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis" International Journal of Molecular Sciences 22, no. 16: 8470. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168470

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