Tamoxifen Application Is Associated with Transiently Increased Loss of Hippocampal Neurons following Virus Infection
Abstract
:1. Introduction
2. Short Experimental Setup
3. Results and Discussion
4. Materials and Methods
4.1. Mice
4.2. TMEV Infection, Tamoxifen Application and Necropsy
4.3. Immunohistochemistry
4.4. Statistics, Figures and Data Generation:
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Group Term | Description | 14 dpi |
---|---|---|
NoTam—no lesion | TMEV-infected B6 mice without tamoxifen application and no neuronal loss in the CA2 | N = 7 |
NoTam—lesion | TMEV-infected B6 mice without tamoxifen application and neuronal loss in the CA2 | N = 5 |
Tam0dpi—lesion | TMEV-infected B6 mice with tamoxifen application 0, 2 and 4 dpi | N = 6 |
Tam5dpi—lesion | TMEV-infected B6 mice with tamoxifen application 5, 7 and 9 dpi | N = 10 |
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Hülskötter, K.; Lühder, F.; Flügel, A.; Herder, V.; Baumgärtner, W. Tamoxifen Application Is Associated with Transiently Increased Loss of Hippocampal Neurons following Virus Infection. Int. J. Mol. Sci. 2021, 22, 8486. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168486
Hülskötter K, Lühder F, Flügel A, Herder V, Baumgärtner W. Tamoxifen Application Is Associated with Transiently Increased Loss of Hippocampal Neurons following Virus Infection. International Journal of Molecular Sciences. 2021; 22(16):8486. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168486
Chicago/Turabian StyleHülskötter, Kirsten, Fred Lühder, Alexander Flügel, Vanessa Herder, and Wolfgang Baumgärtner. 2021. "Tamoxifen Application Is Associated with Transiently Increased Loss of Hippocampal Neurons following Virus Infection" International Journal of Molecular Sciences 22, no. 16: 8486. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168486