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Article

Longitudinal and Transverse Relaxivity Analysis of Native Ferritin and Magnetoferritin at 7 T MRI

1
Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia
2
Institute of Hydrology, Slovak Academy of Sciences, Dubravska Cesta 9, 841 04 Bratislava, Slovakia
3
Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia
4
Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Kosice, Slovakia
*
Author to whom correspondence should be addressed.
Academic Editors: Alexander A. Kamnev and Ernest Giralt
Int. J. Mol. Sci. 2021, 22(16), 8487; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168487
Received: 3 June 2021 / Revised: 19 July 2021 / Accepted: 3 August 2021 / Published: 6 August 2021
(This article belongs to the Special Issue Nanoparticles: From Synthesis to Properties)
Magnetite mineralization in human tissue is associated with various pathological processes, especially neurodegenerative disorders. Ferritin’s mineral core is believed to be a precursor of magnetite mineralization. Magnetoferritin (MF) was prepared with different iron loading factors (LFs) as a model system for pathological ferritin to analyze its MRI relaxivity properties compared to those of native ferritin (NF). The results revealed that MF differs statistically significantly from NF, with the same LF, for all studied relaxation parameters at 7 T: r1, r2, r2*, r2/r1, r2*/r1. Distinguishability of MF from NF may be useful in non-invasive MRI diagnosis of pathological processes associated with iron accumulation and magnetite mineralization (e.g., neurodegenerative disorders, cancer, and diseases of the heart, lung and liver). In addition, it was found that MF samples possess very strong correlation and MF’s relaxivity is linearly dependent on the LF, and the transverse and longitudinal ratios r2/r1 and r2*/r1 possess complementary information. This is useful in eliminating false-positive hypointensive artefacts and diagnosis of the different stages of pathology. These findings could contribute to the exploitation of MRI techniques in the non-invasive diagnosis of iron-related pathological processes in human tissue. View Full-Text
Keywords: native ferritin; magnetoferritin; loading factor; MRI; relaxation; longitudinal and transverse relaxivity native ferritin; magnetoferritin; loading factor; MRI; relaxation; longitudinal and transverse relaxivity
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MDPI and ACS Style

Strbak, O.; Balejcikova, L.; Kmetova, M.; Gombos, J.; Kovac, J.; Dobrota, D.; Kopcansky, P. Longitudinal and Transverse Relaxivity Analysis of Native Ferritin and Magnetoferritin at 7 T MRI. Int. J. Mol. Sci. 2021, 22, 8487. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168487

AMA Style

Strbak O, Balejcikova L, Kmetova M, Gombos J, Kovac J, Dobrota D, Kopcansky P. Longitudinal and Transverse Relaxivity Analysis of Native Ferritin and Magnetoferritin at 7 T MRI. International Journal of Molecular Sciences. 2021; 22(16):8487. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168487

Chicago/Turabian Style

Strbak, Oliver, Lucia Balejcikova, Martina Kmetova, Jan Gombos, Jozef Kovac, Dusan Dobrota, and Peter Kopcansky. 2021. "Longitudinal and Transverse Relaxivity Analysis of Native Ferritin and Magnetoferritin at 7 T MRI" International Journal of Molecular Sciences 22, no. 16: 8487. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168487

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