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Review

The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets

1
Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine [UO VGAVM], 7/11 Dovatora Str., 210026 Vitebsk, Belarus
2
Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia
3
Laboratory of Angiopathology, The Institute of General Pathology and Pathophysiology, 8 Baltiyskaya Street, 125315 Moscow, Russia
4
Federal Research Centre for Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Passage, 109240 Moscow, Russia
5
Therapy Faculty, Pirogov Russian National Research Medical University, 1 Ostrovitianov Street, 117997 Moscow, Russia
6
V.A. Nasonova Institute of Rheumatology, 34A Kashirskoye Shosse, 115522 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Anna Atlante
Int. J. Mol. Sci. 2021, 22(16), 8770; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168770
Received: 25 July 2021 / Revised: 12 August 2021 / Accepted: 13 August 2021 / Published: 16 August 2021
Mitochondria-derived peptides (MDPs) are small peptides hidden in the mitochondrial DNA, maintaining mitochondrial function and protecting cells under different stresses. Currently, three types of MDPs have been identified: Humanin, MOTS-c and SHLP1-6. MDPs have demonstrated anti-apoptotic and anti-inflammatory activities, reactive oxygen species and oxidative stress-protecting properties both in vitro and in vivo. Recent research suggests that MDPs have a significant cardioprotective role, affecting CVDs (cardiovascular diseases) development and progression. CVDs are the leading cause of death globally; this term combines disorders of the blood vessels and heart. In this review, we focus on the recent progress in understanding the relationships between MDPs and the main cardiovascular risk factors (atherosclerosis, insulin resistance, hyperlipidaemia and ageing). We also will discuss the therapeutic application of MDPs, modified and synthetic MDPs, and their potential as novel biomarkers and therapeutic targets. View Full-Text
Keywords: mitochondria-derived peptides; cardiovascular diseases; Humanin; MOTS-c; SHLPs; atherosclerosis; insulin resistance; hyperlipidaemia; ageing mitochondria-derived peptides; cardiovascular diseases; Humanin; MOTS-c; SHLPs; atherosclerosis; insulin resistance; hyperlipidaemia; ageing
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MDPI and ACS Style

Dabravolski, S.A.; Nikiforov, N.G.; Starodubova, A.V.; Popkova, T.V.; Orekhov, A.N. The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets. Int. J. Mol. Sci. 2021, 22, 8770. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168770

AMA Style

Dabravolski SA, Nikiforov NG, Starodubova AV, Popkova TV, Orekhov AN. The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets. International Journal of Molecular Sciences. 2021; 22(16):8770. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168770

Chicago/Turabian Style

Dabravolski, Siarhei A., Nikita G. Nikiforov, Antonina V. Starodubova, Tatyana V. Popkova, and Alexander N. Orekhov 2021. "The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets" International Journal of Molecular Sciences 22, no. 16: 8770. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168770

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