Next Article in Journal
Obesity Has a Systemic Effect on Immune Cells in Naïve and Cancer-Bearing Mice
Next Article in Special Issue
Trace Amine-Associated Receptor 1 Contributes to Diverse Functional Actions of O-Phenyl-Iodotyramine in Mice but Not to the Effects of Monoamine-Based Antidepressants
Previous Article in Journal
Rosmarinic Acid Increases Macrophage Cholesterol Efflux through Regulation of ABCA1 and ABCG1 in Different Mechanisms
Previous Article in Special Issue
A Role for Xanthurenic Acid in the Control of Brain Dopaminergic Activity
Article

Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis

1
Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7/9, 199034 St. Petersburg, Russia
2
St. Petersburg University Hospital, St. Petersburg State University, Universitetskaya nab. 7/9, 199034 St. Petersburg, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Grazia Rutigliano
Int. J. Mol. Sci. 2021, 22(16), 8802; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168802
Received: 16 July 2021 / Revised: 11 August 2021 / Accepted: 12 August 2021 / Published: 16 August 2021
(This article belongs to the Special Issue Trace Amine-Associated Receptors in Neuropsychiatric Disorders)
Trace amine-associated receptors (TAAR) recognize organic compounds, including primary, secondary, and tertiary amines. The TAAR5 receptor is known to be involved in the olfactory sensing of innate socially relevant odors encoded by volatile amines. However, emerging data point to the involvement of TAAR5 in brain functions, particularly in the emotional behaviors mediated by the limbic system which suggests its potential contribution to the pathogenesis of neuropsychiatric diseases. TAAR5 expression was explored in datasets available in the Gene Expression Omnibus, Allen Brain Atlas, and Human Protein Atlas databases. Transcriptomic data demonstrate ubiquitous low TAAR5 expression in the cortical and limbic brain areas, the amygdala and the hippocampus, the nucleus accumbens, the thalamus, the hypothalamus, the basal ganglia, the cerebellum, the substantia nigra, and the white matter. Altered TAAR5 expression is identified in Down syndrome, major depressive disorder, or HIV-associated encephalitis. Taken together, these data indicate that TAAR5 in humans is expressed not only in the olfactory system but also in certain brain structures, including the limbic regions receiving olfactory input and involved in critical brain functions. Thus, TAAR5 can potentially be involved in the pathogenesis of brain disorders and represents a valuable novel target for neuropsychopharmacology. View Full-Text
Keywords: trace amines; trace amine-associated receptor; TAAR; TAAR5; human brain; brain cortex; striatum; white matter; major depressive disorder; HIV-encephalitis; Down syndrome trace amines; trace amine-associated receptor; TAAR; TAAR5; human brain; brain cortex; striatum; white matter; major depressive disorder; HIV-encephalitis; Down syndrome
Show Figures

Figure 1

MDPI and ACS Style

Vaganova, A.N.; Murtazina, R.Z.; Shemyakova, T.S.; Prjibelski, A.D.; Katolikova, N.V.; Gainetdinov, R.R. Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis. Int. J. Mol. Sci. 2021, 22, 8802. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168802

AMA Style

Vaganova AN, Murtazina RZ, Shemyakova TS, Prjibelski AD, Katolikova NV, Gainetdinov RR. Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis. International Journal of Molecular Sciences. 2021; 22(16):8802. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168802

Chicago/Turabian Style

Vaganova, Anastasia N., Ramilya Z. Murtazina, Taisiia S. Shemyakova, Andrey D. Prjibelski, Nataliia V. Katolikova, and Raul R. Gainetdinov. 2021. "Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis" International Journal of Molecular Sciences 22, no. 16: 8802. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168802

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop