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Review

The Impact of Probiotics on Intestinal Mucositis during Chemotherapy for Colorectal Cancer: A Comprehensive Review of Animal Studies

1
General, Visceral and Transplant Surgery, Department of Surgery, Medical University of Graz, Auenbruggerpl. 2, 8036 Graz, Austria
2
Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Academic Editors: Andreas Schwiertz and Athanasios G. Papavassiliou
Int. J. Mol. Sci. 2021, 22(17), 9347; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179347
Received: 29 June 2021 / Revised: 26 July 2021 / Accepted: 21 August 2021 / Published: 28 August 2021
(This article belongs to the Special Issue Recent Advances and Future Perspective in Microbiota and Probiotics)
Colorectal cancer (CRC) is the second most commonly diagnosed cancer in females (incidence 16.4/10,000) and the third in males (incidence 23.4/10,000) worldwide. Surgery, chemotherapy (CTx), radiation therapy (RTx), or a combined treatment of those are the current treatment modalities for primary CRC. Chemotherapeutic drug-induced gastrointestinal (GIT) toxicity mainly presents as mucositis and diarrhea. Preclinical studies revealed that probiotic supplementation helps prevent CTx-induced side effects by reducing oxidative stress and proinflammatory cytokine production and promoting crypt cell proliferation. Moreover, probiotics showed significant results in preventing the loss of body weight (BW) and reducing diarrhea. However, further clinical studies are needed to elucidate the exact doses and most promising combination of strains to reduce or prevent chemotherapy-induced side effects. The aim of this review is to overview currently available literature on the impact of probiotics on CTx-induced side effects in animal studies concerning CRC treatment and discuss the potential mechanisms based on experimental studies’ outcomes. View Full-Text
Keywords: gut microbiota; dysbiosis; proinflammatory cytokines gut microbiota; dysbiosis; proinflammatory cytokines
  • Externally hosted supplementary file 1
    Doi: 10.5281/zenodo.5043406
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MDPI and ACS Style

Miknevicius, P.; Zulpaite, R.; Leber, B.; Strupas, K.; Stiegler, P.; Schemmer, P. The Impact of Probiotics on Intestinal Mucositis during Chemotherapy for Colorectal Cancer: A Comprehensive Review of Animal Studies. Int. J. Mol. Sci. 2021, 22, 9347. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179347

AMA Style

Miknevicius P, Zulpaite R, Leber B, Strupas K, Stiegler P, Schemmer P. The Impact of Probiotics on Intestinal Mucositis during Chemotherapy for Colorectal Cancer: A Comprehensive Review of Animal Studies. International Journal of Molecular Sciences. 2021; 22(17):9347. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179347

Chicago/Turabian Style

Miknevicius, Povilas, Ruta Zulpaite, Bettina Leber, Kestutis Strupas, Philipp Stiegler, and Peter Schemmer. 2021. "The Impact of Probiotics on Intestinal Mucositis during Chemotherapy for Colorectal Cancer: A Comprehensive Review of Animal Studies" International Journal of Molecular Sciences 22, no. 17: 9347. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179347

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