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Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions

1
Department of Veterinary Sciences, University of Turin, Largo Braccini 2, 10095 Grugliasco, TO, Italy
2
Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, 10043 Orbassano, TO, Italy
3
Center for Neuroscience, Delaware State University, Dover, DE 19901, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Anna-Leena Sirén
Int. J. Mol. Sci. 2021, 22(17), 9358; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179358
Received: 29 July 2021 / Revised: 26 August 2021 / Accepted: 26 August 2021 / Published: 28 August 2021
(This article belongs to the Special Issue Neuron and Brain Maturation)
Plasticity, and in particular, neurogenesis, is a promising target to treat and prevent a wide variety of diseases (e.g., epilepsy, stroke, dementia). There are different types of plasticity, which vary with age, brain region, and species. These observations stress the importance of defining plasticity along temporal and spatial dimensions. We review recent studies focused on brain plasticity across the lifespan and in different species. One main theme to emerge from this work is that plasticity declines with age but that we have yet to map these different forms of plasticity across species. As part of this effort, we discuss our recent progress aimed to identify corresponding ages across species, and how this information can be used to map temporal variation in plasticity from model systems to humans. View Full-Text
Keywords: neurogenesis; immature neurons; translating time; mammals; doublecortin; PSA-NCAM neurogenesis; immature neurons; translating time; mammals; doublecortin; PSA-NCAM
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MDPI and ACS Style

Bonfanti, L.; Charvet, C.J. Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions. Int. J. Mol. Sci. 2021, 22, 9358. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179358

AMA Style

Bonfanti L, Charvet CJ. Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions. International Journal of Molecular Sciences. 2021; 22(17):9358. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179358

Chicago/Turabian Style

Bonfanti, Luca, and Christine J. Charvet. 2021. "Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions" International Journal of Molecular Sciences 22, no. 17: 9358. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179358

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