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Review

Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways

by 1, 1,* and 2,*
1
School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
2
UniSA Clinical & Health Science, City West Campus, University of South Australia, Adelaide, SA 5001, Australia
*
Authors to whom correspondence should be addressed.
Academic Editor: Barbara Mroczko
Int. J. Mol. Sci. 2021, 22(17), 9474; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179474
Received: 10 August 2021 / Revised: 26 August 2021 / Accepted: 28 August 2021 / Published: 31 August 2021
(This article belongs to the Special Issue Molecular Biomarkers of Selected Diseases of Civilization 2.0)
Chemotherapy-induced intestinal mucositis, a painful debilitating condition affecting up to 40–100% of patients undergoing chemotherapy, can reduce the patients’ quality of life, add health care costs and even postpone cancer treatment. In recent years, the relationships between intestinal microbiota dysbiosis and mucositis have drawn much attention in mucositis research. Chemotherapy can shape intestinal microbiota, which, in turn, can aggravate the mucositis through toll-like receptor (TLR) signaling pathways, leading to an increased expression of inflammatory mediators and elevated epithelial cell apoptosis but decreased epithelial cell differentiation and mucosal regeneration. This review summarizes relevant studies related to the relationships of mucositis with chemotherapy regimens, microbiota, TLRs, inflammatory mediators, and intestinal homeostasis, aiming to explore how gut microbiota affects the pathogenesis of mucositis and provides potential new strategies for mucositis alleviation and treatment and development of new therapies. View Full-Text
Keywords: chemotherapy; mucositis; intestinal microbiota dysbiosis; toll-like receptors chemotherapy; mucositis; intestinal microbiota dysbiosis; toll-like receptors
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MDPI and ACS Style

Wei, L.; Wen, X.-S.; Xian, C.J. Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways. Int. J. Mol. Sci. 2021, 22, 9474. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179474

AMA Style

Wei L, Wen X-S, Xian CJ. Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways. International Journal of Molecular Sciences. 2021; 22(17):9474. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179474

Chicago/Turabian Style

Wei, Ling, Xue-Sen Wen, and Cory J. Xian 2021. "Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways" International Journal of Molecular Sciences 22, no. 17: 9474. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179474

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