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Article

Centrosome, the Newly Identified Passenger through Tunneling Nanotubes, Increases Binucleation and Proliferation Marker in Receiving Cells

1
Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP CYCERON, F-14000 Caen, France
2
Department of Pathology, CHU de Caen, F-14000 Caen, France
3
Normandie University, UNIROUEN, INSERM, PRIMACEN, F-76000 Rouen, France
4
Normandie University, UNICAEN, SFR ICORE, Plateau CMABio3, F-14033 Caen, France
5
Normandie University, UNIHAVRE, UMR-I 02 INERIS-URCA-ULH SEBIO FR CNRS 3730 Scale, CEDEX, F-76063 Le Havre, France
6
Department of Pulmonology & Thoracic Oncology, CHU de Caen, F-14033 Caen, France
*
Author to whom correspondence should be addressed.
Academic Editor: Ana Joaquina Perez-Berna
Int. J. Mol. Sci. 2021, 22(18), 9680; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189680
Received: 15 July 2021 / Revised: 26 August 2021 / Accepted: 2 September 2021 / Published: 7 September 2021
(This article belongs to the Special Issue Cellular Structural Biology)
Type 1 tunneling nanotubes (TNTs-1) are long, cytoplasmic protrusions containing actin, microtubules and intermediate filaments that provide a bi-directional road for the transport of various components between distant cells. TNT-1 formation is accompanied by dramatic cytoskeletal reorganization offering mechanical support for intercellular communication. Although the centrosome is the major microtubule nucleating center and also a signaling hub, the relationship between the centrosome and TNTs-1 is still unexplored. We provide here the first evidence of centrosome localization and orientation towards the TNTs-1 protrusion site, which is implicated in TNT-1 formation. We also envision a model whereby synchronized reorientation of the Golgi apparatus along with the centrosome towards TNTs-1 ensures effective polarized trafficking through TNTs-1. Furthermore, using immunohistochemistry and live imaging, we observed for the first time the movement of an extra centrosome within TNTs-1. In this regard, we hypothesize a novel role for TNTs-1 as a critical pathway serving to displace extra centrosomes and potentially to either protect malignant cells against aberrant centrosome amplification or contribute to altering cells in the tumor environment. Indeed, we have observed the increase in binucleation and proliferation markers in receiving cells. The fact that the centrosome can be both as the base and the user of TNTs-1 offers new perspectives and new opportunities to follow in order to improve our knowledge of the pathophysiological mechanisms under TNT control. View Full-Text
Keywords: tunneling nanotubes; centrosome; tumor development tunneling nanotubes; centrosome; tumor development
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MDPI and ACS Style

Dubois, F.; Galas, L.; Elie, N.; Le Foll, F.; Bazille, C.; Bergot, E.; Levallet, G. Centrosome, the Newly Identified Passenger through Tunneling Nanotubes, Increases Binucleation and Proliferation Marker in Receiving Cells. Int. J. Mol. Sci. 2021, 22, 9680. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189680

AMA Style

Dubois F, Galas L, Elie N, Le Foll F, Bazille C, Bergot E, Levallet G. Centrosome, the Newly Identified Passenger through Tunneling Nanotubes, Increases Binucleation and Proliferation Marker in Receiving Cells. International Journal of Molecular Sciences. 2021; 22(18):9680. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189680

Chicago/Turabian Style

Dubois, Fatéméh, Ludovic Galas, Nicolas Elie, Frank Le Foll, Céline Bazille, Emmanuel Bergot, and Guénaëlle Levallet. 2021. "Centrosome, the Newly Identified Passenger through Tunneling Nanotubes, Increases Binucleation and Proliferation Marker in Receiving Cells" International Journal of Molecular Sciences 22, no. 18: 9680. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189680

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