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The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in Osteoarthritis

Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert Koch Straße 40, 37075 Göttingen, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Chunyi Wen
Int. J. Mol. Sci. 2021, 22(18), 9887; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189887
Received: 13 August 2021 / Revised: 7 September 2021 / Accepted: 9 September 2021 / Published: 13 September 2021
(This article belongs to the Special Issue Novel Osteoarthritis Pathogenesis and Management)
Osteoarthritis (OA) is a chronic disease affecting the whole joint, which still lacks a disease-modifying treatment. This suggests an incomplete understanding of underlying molecular mechanisms. The Wnt/β-catenin pathway is involved in different pathophysiological processes of OA. Interestingly, both excessive stimulation and suppression of this pathway can contribute to the pathogenesis of OA. microRNAs have been shown to regulate different cellular processes in different diseases, including the metabolic activity of chondrocytes and osteocytes. To bridge these findings, here we attempt to give a conclusive overview of microRNA regulation of the Wnt/β-catenin pathway in bone and cartilage, which may provide insights to advance the development of miRNA-based therapeutics for OA treatment. View Full-Text
Keywords: osteoarthritis; Wnt/β-catenin; miRNA; non-coding RNA osteoarthritis; Wnt/β-catenin; miRNA; non-coding RNA
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MDPI and ACS Style

Shang, X.; Böker, K.O.; Taheri, S.; Hawellek, T.; Lehmann, W.; Schilling, A.F. The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in Osteoarthritis. Int. J. Mol. Sci. 2021, 22, 9887. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189887

AMA Style

Shang X, Böker KO, Taheri S, Hawellek T, Lehmann W, Schilling AF. The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in Osteoarthritis. International Journal of Molecular Sciences. 2021; 22(18):9887. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189887

Chicago/Turabian Style

Shang, Xiaobin, Kai O. Böker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, and Arndt F. Schilling 2021. "The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in Osteoarthritis" International Journal of Molecular Sciences 22, no. 18: 9887. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189887

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