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Parasite Survival and Disease Persistence in Cystic Fibrosis, Schistosomiasis and Pathogenic Bacterial Diseases: A Role for Universal Stress Proteins?

Molecular Biophysics and Structural Biology (MBSB) Group, Department of Biochemistry, Kingsway Campus, University of Johannesburg, Auckland Park 2006, South Africa
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Academic Editor: Claudiu T. Supuran
Int. J. Mol. Sci. 2021, 22(19), 10878; https://doi.org/10.3390/ijms221910878
Received: 22 July 2021 / Revised: 15 September 2021 / Accepted: 28 September 2021 / Published: 8 October 2021
(This article belongs to the Section Biochemistry)
Universal stress proteins (USPs) were originally discovered in Escherichia coli over two decades ago and since then their presence has been detected in various organisms that include plants, archaea, metazoans, and bacteria. As their name suggests, they function in a series of various cellular responses in both abiotic and biotic stressful conditions such as oxidative stress, exposure to DNA damaging agents, nutrient starvation, high temperature and acidic stress, among others. Although a highly conserved group of proteins, the molecular and biochemical aspects of their functions are largely evasive. This is concerning, as it was observed that USPs act as essential contributors to the survival/persistence of various infectious pathogens. Their ubiquitous nature in various organisms, as well as their augmentation during conditions of stress, is a clear indication of their direct or indirect importance in providing resilience against such conditions. This paper seeks to clarify what has already been reported in the literature on the proposed mechanism of action of USPs in pathogenic organisms. View Full-Text
Keywords: cystic fibrosis; Escherichia coli; schistosomiasis; tuberculosis; universal stress protein cystic fibrosis; Escherichia coli; schistosomiasis; tuberculosis; universal stress protein
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MDPI and ACS Style

Masamba, P.; Kappo, A.P. Parasite Survival and Disease Persistence in Cystic Fibrosis, Schistosomiasis and Pathogenic Bacterial Diseases: A Role for Universal Stress Proteins? Int. J. Mol. Sci. 2021, 22, 10878. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910878

AMA Style

Masamba P, Kappo AP. Parasite Survival and Disease Persistence in Cystic Fibrosis, Schistosomiasis and Pathogenic Bacterial Diseases: A Role for Universal Stress Proteins? International Journal of Molecular Sciences. 2021; 22(19):10878. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910878

Chicago/Turabian Style

Masamba, Priscilla, and Abidemi P. Kappo. 2021. "Parasite Survival and Disease Persistence in Cystic Fibrosis, Schistosomiasis and Pathogenic Bacterial Diseases: A Role for Universal Stress Proteins?" International Journal of Molecular Sciences 22, no. 19: 10878. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910878

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