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Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer

Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 727; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020727
Received: 20 December 2020 / Revised: 4 January 2021 / Accepted: 8 January 2021 / Published: 13 January 2021
(This article belongs to the Special Issue Biological Interfaces in Gastrointestinal Cancer)
Interleukin (IL)-4 and -13 are structurally and functionally related cytokines sharing common receptor subunits. They regulate immune responses and, moreover, are involved in the pathogenesis of a variety of human neoplasms. Three different receptors have been described for IL-4, but only IL-4 receptor type II (IL-4Rα/IL-13Rα1) is expressed in solid tumors. While IL-13 can also bind to three different receptors, IL-13 receptor type I (IL-4Rα/IL-13Rα1/IL-13Rα2) and type II (IL-4Rα/IL-13Rα1) are expressed in solid tumors. After receptor binding, IL-4 and IL-13 can mediate tumor cell proliferation, survival, and metastasis in gastric or colon cancer. This review summarizes the results about the role of IL-4/IL-13 and their receptors in gastric and colon cancer. View Full-Text
Keywords: interleukin-4; interleukin-13; interleukin-4 receptor; interleukin-13 receptor; gastrointestinal cancer interleukin-4; interleukin-13; interleukin-4 receptor; interleukin-13 receptor; gastrointestinal cancer
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MDPI and ACS Style

Song, X.; Traub, B.; Shi, J.; Kornmann, M. Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer. Int. J. Mol. Sci. 2021, 22, 727. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020727

AMA Style

Song X, Traub B, Shi J, Kornmann M. Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer. International Journal of Molecular Sciences. 2021; 22(2):727. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020727

Chicago/Turabian Style

Song, Xujun, Benno Traub, Jingwei Shi, and Marko Kornmann. 2021. "Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer" International Journal of Molecular Sciences 22, no. 2: 727. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020727

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