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Implications of a Soy-Based Diet for Animal Models

Université de Nantes, CHU Nantes, CNRS, INSERM, L’institut du Thorax, F-44000 Nantes, France
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2021, 22(2), 774;
Received: 26 November 2020 / Revised: 29 December 2020 / Accepted: 12 January 2021 / Published: 14 January 2021
(This article belongs to the Special Issue Metabolic Therapies for Heart Failure)
The use of animal models in fundamental or pre-clinical research remains an absolute requirement for understanding human pathologies and developing new drugs. In order to transpose these results into clinical practice, many parameters must be taken into account to limit bias. Attention has recently been focused on the sex, age or even strain of each animal, but the impact of diet has been largely neglected. Soy, which is commonly used in the diet in varying quantities can affect their physiology. In order to assess whether the presence of soy can impact the obtained results, we studied the impact of a soy-based diet versus a soy-free diet, on diastolic function in a rat model based on transgenic overexpression of the β3-adrenergic receptors in the endothelium and characterized by the appearance of diastolic dysfunction with age. Our results show that the onset of diastolic dysfunction is only observed in transgenic male rats fed with a soy-free diet in the long term. Our study highlights the importance of the diet’s choice in the study design process, especially regarding the proportion of soy, to correctly interpret the outcome as low-cost diets are more likely to be highly concentrated in soy. View Full-Text
Keywords: phytoestrogen; soy-based diet; sex; endothelium; diastolic function phytoestrogen; soy-based diet; sex; endothelium; diastolic function
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MDPI and ACS Style

Dhot, J.; Prat, V.; Ferron, M.; Aillerie, V.; Erraud, A.; Rozec, B.; Waard, M.D.; Gauthier, C.; Lauzier, B. Implications of a Soy-Based Diet for Animal Models. Int. J. Mol. Sci. 2021, 22, 774.

AMA Style

Dhot J, Prat V, Ferron M, Aillerie V, Erraud A, Rozec B, Waard MD, Gauthier C, Lauzier B. Implications of a Soy-Based Diet for Animal Models. International Journal of Molecular Sciences. 2021; 22(2):774.

Chicago/Turabian Style

Dhot, Justine, Valentine Prat, Marine Ferron, Virginie Aillerie, Angélique Erraud, Bertrand Rozec, Michel D. Waard, Chantal Gauthier, and Benjamin Lauzier. 2021. "Implications of a Soy-Based Diet for Animal Models" International Journal of Molecular Sciences 22, no. 2: 774.

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