Next Article in Journal
Survival Pathways Are Differently Affected by Microgravity in Normal and Cancerous Breast Cells
Next Article in Special Issue
Role of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation and Subsequent Immune Challenge in the Behaviour and Microglial Cell Trajectory in Adult Offspring: A Study of the Neurodevelopmental Model of Schizophrenia
Previous Article in Journal
Molecular Aspects of Pruritus Pathogenesis in Psoriasis
Previous Article in Special Issue
Solid Lipid Curcumin Particles Protect Medium Spiny Neuronal Morphology, and Reduce Learning and Memory Deficits in the YAC128 Mouse Model of Huntington’s Disease
Article

Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer’s Disease

1
Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mount Pleasant, MI 48859, USA
2
Program in Neuroscience, Central Michigan University, Mount Pleasant, MI 48859, USA
3
Insight Research Center, Insight Institute of Neurosurgery and Neuroscience, Flint, MI 48607, USA
4
Physician Assistant Program, Central Michigan University, Mount Pleasant, MI 48859, USA
5
College of Medicine, Central Michigan University, Mount Pleasant, MI 48859, USA
6
Field Neurosciences Institute, Ascension St. Mary’s, Saginaw, MI 48604, USA
7
Department of Psychology, Central Michigan University, Mount Pleasant, MI 48859, USA
8
College of Health and Human Services, Saginaw Valley State University, Saginaw, MI 48710, USA
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 860; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020860
Received: 18 December 2020 / Revised: 7 January 2021 / Accepted: 14 January 2021 / Published: 16 January 2021
(This article belongs to the Collection Neuroinflammatory Processes in Neurodegenerative Diseases)
Recent clinical and epidemiological studies support the contention that diabetes mellitus (DM) is a strong risk factor for the development of Alzheimer’s disease (AD). The use of insulin cell toxin, streptozotocin (STZ), when injected into the lateral ventricles, develops an insulin resistant brain state (IRBS) and represents a non-transgenic, or sporadic AD model (SAD), with several AD-like neuropathological features. The present study explored the effects of an anti-diabetic drug, liraglutide (LIR), in reversing major pathological hallmarks in the prodromal disease stage of both the 5xFAD transgenic and SAD mouse models of AD. Three-month-old 5xFAD and age-matched wild type mice were given a single intracerebroventricular (i.c.v) injection of STZ or vehicle (saline) and were subsequently treated with LIR, intraperitoneally (IP), once a day for 30 days. The extent of neurodegeneration, Aβ plaque load, and key proteins associated with the insulin signaling pathways were measured using Western blot and neuroinflammation (via immunohistological assays) in the cortical and hippocampal regions of the brain were assessed following a series of behavioral tests used to measure cognitive function after LIR or vehicle treatments. Our results indicated that STZ significantly increased neuroinflammation, Aβ plaque deposition and disrupted insulin signaling pathway, while 25 nmol/kg LIR, when injected IP, significantly decreased neuroinflammatory responses in both SAD and 5xFAD mice before significant cognitive changes were observed, suggesting LIR can reduce early neuropathology markers prior to the emergence of overt memory deficits. Our results indicate that LIR has neuroprotective effects and has the potential to serve as an anti-inflammatory and anti-amyloid prophylactic therapy in the prodromal stages of AD. View Full-Text
Keywords: Alzheimer’s disease; liraglutide; streptozotocin; neuroinflammation; amyloid beta protein; sporadic Alzheimer’s disease; diabetes mellitus Alzheimer’s disease; liraglutide; streptozotocin; neuroinflammation; amyloid beta protein; sporadic Alzheimer’s disease; diabetes mellitus
Show Figures

Figure 1

MDPI and ACS Style

Paladugu, L.; Gharaibeh, A.; Kolli, N.; Learman, C.; Hall, T.C.; Li, L.; Rossignol, J.; Maiti, P.; Dunbar, G.L. Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer’s Disease. Int. J. Mol. Sci. 2021, 22, 860. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020860

AMA Style

Paladugu L, Gharaibeh A, Kolli N, Learman C, Hall TC, Li L, Rossignol J, Maiti P, Dunbar GL. Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer’s Disease. International Journal of Molecular Sciences. 2021; 22(2):860. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020860

Chicago/Turabian Style

Paladugu, Leela; Gharaibeh, Abeer; Kolli, Nivya; Learman, Cameron; Hall, Tia C.; Li, Lixin; Rossignol, Julien; Maiti, Panchanan; Dunbar, Gary L. 2021. "Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer’s Disease" Int. J. Mol. Sci. 22, no. 2: 860. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020860

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop