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Review

The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery

1
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
2
Department of Movement Sciences and Wellbeing, Parthenope University of Naples, 80133 Naples, Italy
3
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 972; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020972
Received: 20 December 2020 / Revised: 8 January 2021 / Accepted: 13 January 2021 / Published: 19 January 2021
The endocannabinoid system (ECS) is a lipid cell signaling system involved in the physiology and homeostasis of the brain and peripheral tissues. Synaptic plasticity, neuroendocrine functions, reproduction, and immune response among others all require the activity of functional ECS, with the onset of disease in case of ECS impairment. Estrogens, classically considered as female steroid hormones, regulate growth, differentiation, and many other functions in a broad range of target tissues and both sexes through the activation of nuclear and membrane estrogen receptors (ERs), which leads to genomic and non-genomic cell responses. Since ECS function overlaps or integrates with many other cell signaling systems, this review aims at updating the knowledge about the possible crosstalk between ECS and estrogen system (ES) at both central and peripheral level, with focuses on the central nervous system, reproduction, and cancer. View Full-Text
Keywords: endocannabinoid system; estrogens; central nervous system; reproduction; cancer endocannabinoid system; estrogens; central nervous system; reproduction; cancer
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MDPI and ACS Style

Santoro, A.; Mele, E.; Marino, M.; Viggiano, A.; Nori, S.L.; Meccariello, R. The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery. Int. J. Mol. Sci. 2021, 22, 972. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020972

AMA Style

Santoro A, Mele E, Marino M, Viggiano A, Nori SL, Meccariello R. The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery. International Journal of Molecular Sciences. 2021; 22(2):972. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020972

Chicago/Turabian Style

Santoro, Antonietta, Elena Mele, Marianna Marino, Andrea Viggiano, Stefania L. Nori, and Rosaria Meccariello. 2021. "The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery" International Journal of Molecular Sciences 22, no. 2: 972. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020972

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