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Article

Recruitment of M1 Macrophages May Not Be Critical for Protection against Colitis-Associated Tumorigenesis

1
Laboratorio Nacional en Salud FES-Iztacala, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de México, Mexico
2
Unidad de Biomedicina, Facultad de Estudios Superiores (FES)-Iztacala, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de México, Mexico
*
Author to whom correspondence should be addressed.
Academic Editors: Andre Lechel and Reinhold Schirmbeck
Int. J. Mol. Sci. 2021, 22(20), 11204; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222011204
Received: 15 September 2021 / Revised: 8 October 2021 / Accepted: 12 October 2021 / Published: 18 October 2021
(This article belongs to the Special Issue Biological Interfaces in Gastrointestinal Cancer 2.0)
A close connection between inflammation and the risk of developing colon cancer has been suggested in the last few years. It has been estimated that patients diagnosed with some types of inflammatory bowel disease, such as ulcerative colitis or Crohn’s disease, have up to a 30% increased risk of developing colon cancer. However, there is also evidence showing that the activation of anti-inflammatory pathways, such as the IL-4 receptor-mediated pathway, may favor the development of colon tumors. Using an experimental model of colitis-associated colon cancer (CAC), we found that the decrease in tumor development in global IL4Rα knockout mice (IL4RαKO) was apparently associated with an inflammatory response mediated by the infiltration of M1 macrophages (F480+TLR2+STAT1+) and iNOS expression in colon tissue. However, when we developed mice with a specific deletion of IL4Rα in macrophages (LysMcreIL4Rα−/lox mice) and subjected them to CAC, it was found that despite presenting a large infiltration of M1 macrophages into the colon, these mice were as susceptible to colon-tumorigenesis as WT mice. These data suggest that in the tumor microenvironment the absence of IL4Rα expression on macrophages, as well as the recruitment of M1 macrophages, may not be directly associated with resistance to developing colon tumors. Therefore, it is possible that IL4Rα expression in other cell types, such as colonic epithelial cells, could have an important role in promoting the development of colitis-associated colon tumorigenesis. View Full-Text
Keywords: colitis-associated colon cancer; inflammation; IL4Rα; macrophages colitis-associated colon cancer; inflammation; IL4Rα; macrophages
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MDPI and ACS Style

Medina-Andrade, I.; Olguín, J.E.; Guerrero-García, S.; Espinosa, J.A.; Garduño-Javier, E.; Hernández-Gómez, V.; Vaca-Paniagua, F.; Rodríguez-Sosa, M.; Terrazas, L.I. Recruitment of M1 Macrophages May Not Be Critical for Protection against Colitis-Associated Tumorigenesis. Int. J. Mol. Sci. 2021, 22, 11204. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222011204

AMA Style

Medina-Andrade I, Olguín JE, Guerrero-García S, Espinosa JA, Garduño-Javier E, Hernández-Gómez V, Vaca-Paniagua F, Rodríguez-Sosa M, Terrazas LI. Recruitment of M1 Macrophages May Not Be Critical for Protection against Colitis-Associated Tumorigenesis. International Journal of Molecular Sciences. 2021; 22(20):11204. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222011204

Chicago/Turabian Style

Medina-Andrade, Itzel, Jonadab E. Olguín, Stephanie Guerrero-García, Jossael A. Espinosa, Elizabeth Garduño-Javier, Victoria Hernández-Gómez, Felipe Vaca-Paniagua, Miriam Rodríguez-Sosa, and Luis I. Terrazas 2021. "Recruitment of M1 Macrophages May Not Be Critical for Protection against Colitis-Associated Tumorigenesis" International Journal of Molecular Sciences 22, no. 20: 11204. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222011204

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