Magnesium Deficiency Induces Lipid Accumulation in Vascular Endothelial Cells via Oxidative Stress—The Potential Contribution of EDF-1 and PPARγ
Abstract
:1. Introduction
2. Results
2.1. Low Magnesium Upregulates EDF-1
2.2. Low Magnesium Induces Oxidative Stress in HUVEC
2.3. EDF-1 Is Induced by Oxidative Stress
2.4. Low Magnesium Induces PPARγ
2.5. Low Magnesium Induces Lipid Accumulation in HUVEC
3. Discussion
4. Materials and Methods
4.1. Cell Culture
4.2. Western Blot Analysis
4.3. ROS Production
4.4. Oil Red O Staining
4.5. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Locatelli, L.; Fedele, G.; Castiglioni, S.; Maier, J.A. Magnesium Deficiency Induces Lipid Accumulation in Vascular Endothelial Cells via Oxidative Stress—The Potential Contribution of EDF-1 and PPARγ. Int. J. Mol. Sci. 2021, 22, 1050. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031050
Locatelli L, Fedele G, Castiglioni S, Maier JA. Magnesium Deficiency Induces Lipid Accumulation in Vascular Endothelial Cells via Oxidative Stress—The Potential Contribution of EDF-1 and PPARγ. International Journal of Molecular Sciences. 2021; 22(3):1050. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031050
Chicago/Turabian StyleLocatelli, Laura, Giorgia Fedele, Sara Castiglioni, and Jeanette A. Maier. 2021. "Magnesium Deficiency Induces Lipid Accumulation in Vascular Endothelial Cells via Oxidative Stress—The Potential Contribution of EDF-1 and PPARγ" International Journal of Molecular Sciences 22, no. 3: 1050. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031050