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Article

Evaluation of Nanotargeted 111In-Cyclic RGDfK-Liposome in a Human Melanoma Xenotransplantation Model

1
Division of Isotope Application, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan
2
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 11221, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Agnes Csiszár
Int. J. Mol. Sci. 2021, 22(3), 1099; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031099
Received: 25 December 2020 / Revised: 16 January 2021 / Accepted: 18 January 2021 / Published: 22 January 2021
(This article belongs to the Special Issue Functionalized Liposomes)
Nanotargeted liposomes may be modified with targeting peptide on the surface of a prepared liposome to endow specificity and elevate targeting efficiency. The aim of this study was to develop a radioactive targeted nanoparticle, the 111In-cyclic RGDfK-liposome, and its advantage of recognizing the αVβ3 integrin was examined. The cyclic RGDfK modified liposomes were demonstrated the ability to bind the αVβ3 integrin expressed on the surface of human melanoma cell in vitro and in vivo. The effects of the cyclic RGDfK-liposome on the functioning of phagocytes was also examined, showing no considerable negative effects on the engulfment of bacteria and the generation of reactive oxygen species. Based upon these findings, the cyclic RGDfK- liposome is said to be a promising agent for tumor imaging. View Full-Text
Keywords: 111In-cyclic RGDfK-liposome; αVβ3 integrin; Nanotargeted liposome 111In-cyclic RGDfK-liposome; αVβ3 integrin; Nanotargeted liposome
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MDPI and ACS Style

Liu, S.-Y.; Lo, S.-N.; Lee, W.-C.; Hsu, W.-C.; Lee, T.-W.; Chang, C.-H. Evaluation of Nanotargeted 111In-Cyclic RGDfK-Liposome in a Human Melanoma Xenotransplantation Model. Int. J. Mol. Sci. 2021, 22, 1099. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031099

AMA Style

Liu S-Y, Lo S-N, Lee W-C, Hsu W-C, Lee T-W, Chang C-H. Evaluation of Nanotargeted 111In-Cyclic RGDfK-Liposome in a Human Melanoma Xenotransplantation Model. International Journal of Molecular Sciences. 2021; 22(3):1099. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031099

Chicago/Turabian Style

Liu, Si-Yen, Sheng-Nan Lo, Wan-Chi Lee, Wei-Chuan Hsu, Te-Wei Lee, and Chih-Hsien Chang. 2021. "Evaluation of Nanotargeted 111In-Cyclic RGDfK-Liposome in a Human Melanoma Xenotransplantation Model" International Journal of Molecular Sciences 22, no. 3: 1099. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031099

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