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Open AccessReview

MSC Based Therapies to Prevent or Treat BPD—A Narrative Review on Advances and Ongoing Challenges

1
Department of General Pediatrics and Neonatology, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Feulgenstrasse 12, 35392 Giessen, Germany
2
Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center (UGMLC), Cardiopulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Aulweg 130, 35392 Giessen, Germany
3
Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Ludwigstrasse 43, 61231 Bad Nauheim, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Sung-Chul Jung
Int. J. Mol. Sci. 2021, 22(3), 1138; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031138
Received: 28 December 2020 / Revised: 19 January 2021 / Accepted: 20 January 2021 / Published: 24 January 2021
Bronchopulmonary dysplasia (BPD) remains one of the most devastating consequences of preterm birth resulting in life-long restrictions in lung function. Distorted lung development is caused by its inflammatory response which is mainly provoked by mechanical ventilation, oxygen toxicity and bacterial infections. Dysfunction of resident lung mesenchymal stem cells (MSC) represents one key hallmark that drives BPD pathology. Despite all progress in the understanding of pathomechanisms, therapeutics to prevent or treat BPD are to date restricted to a few drugs. The limited therapeutic efficacy of established drugs can be explained by the fact that they fail to concurrently tackle the broad spectrum of disease driving mechanisms and by the huge overlap between distorted signal pathways of lung development and inflammation. The great enthusiasm about MSC based therapies as novel therapeutic for BPD arises from the capacity to inhibit inflammation while simultaneously promoting lung development and repair. Preclinical studies, mainly performed in rodents, raise hopes that there will be finally a broadly acting, efficient therapy at hand to prevent or treat BPD. Our narrative review gives a comprehensive overview on preclinical achievements, results from first early phase clinical studies and challenges to a successful translation into the clinical setting. View Full-Text
Keywords: chronic lung disease; bronchopulmonary dysplasia; preterm; mesenchymal stem cells; lung development; inflammation; lung injury; lung repair; extracellular vesicles chronic lung disease; bronchopulmonary dysplasia; preterm; mesenchymal stem cells; lung development; inflammation; lung injury; lung repair; extracellular vesicles
MDPI and ACS Style

Goetz, M.J.; Kremer, S.; Behnke, J.; Staude, B.; Shahzad, T.; Holzfurtner, L.; Chao, C.-M.; Morty, R.E.; Bellusci, S.; Ehrhardt, H. MSC Based Therapies to Prevent or Treat BPD—A Narrative Review on Advances and Ongoing Challenges. Int. J. Mol. Sci. 2021, 22, 1138. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031138

AMA Style

Goetz MJ, Kremer S, Behnke J, Staude B, Shahzad T, Holzfurtner L, Chao C-M, Morty RE, Bellusci S, Ehrhardt H. MSC Based Therapies to Prevent or Treat BPD—A Narrative Review on Advances and Ongoing Challenges. International Journal of Molecular Sciences. 2021; 22(3):1138. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031138

Chicago/Turabian Style

Goetz, Maurizio J.; Kremer, Sarah; Behnke, Judith; Staude, Birte; Shahzad, Tayyab; Holzfurtner, Lena; Chao, Cho-Ming; Morty, Rory E.; Bellusci, Saverio; Ehrhardt, Harald. 2021. "MSC Based Therapies to Prevent or Treat BPD—A Narrative Review on Advances and Ongoing Challenges" Int. J. Mol. Sci. 22, no. 3: 1138. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031138

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