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Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review
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Emerging Role of Neutrophils in the Thrombosis of Chronic Myeloproliferative Neoplasms

1
Hematology and Medical Oncology Department, Hospital Universitario Morales-Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, 30120 Murcia, Spain
2
CIBERER CB15/00055, 28029 Murcia, Spain
3
Grade of Medicine, Faculty of Health Sciences, Catholic University of Murcia (UCAM), 30107 Murcia, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Khaled M. Musallam
Int. J. Mol. Sci. 2021, 22(3), 1143; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031143
Received: 21 December 2020 / Revised: 10 January 2021 / Accepted: 20 January 2021 / Published: 24 January 2021
(This article belongs to the Special Issue Myelofibrosis and Myeloproliferative Neoplasms: Molecular Basis)
Thrombosis is a major cause of morbimortality in patients with chronic Philadelphia chromosome-negative myeloproliferative neoplasms (MPN). In the last decade, multiple lines of evidence support the role of leukocytes in thrombosis of MPN patients. Besides the increase in the number of cells, neutrophils and monocytes of MPN patients show a pro-coagulant activated phenotype. Once activated, neutrophils release structures composed of DNA, histones, and granular proteins, called extracellular neutrophil traps (NETs), which in addition to killing pathogens, provide an ideal matrix for platelet activation and coagulation mechanisms. Herein, we review the published literature related to the involvement of NETs in the pathogenesis of thrombosis in the setting of MPN; the effect that cytoreductive therapies and JAK inhibitors can have on markers of NETosis, and, finally, the novel therapeutic strategies targeting NETs to reduce the thrombotic complications in these patients. View Full-Text
Keywords: myeloproliferative neoplasms; neutrophils; thrombosis; NETs myeloproliferative neoplasms; neutrophils; thrombosis; NETs
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MDPI and ACS Style

Ferrer-Marín, F.; Cuenca-Zamora, E.J.; Guijarro-Carrillo, P.J.; Teruel-Montoya, R. Emerging Role of Neutrophils in the Thrombosis of Chronic Myeloproliferative Neoplasms. Int. J. Mol. Sci. 2021, 22, 1143. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031143

AMA Style

Ferrer-Marín F, Cuenca-Zamora EJ, Guijarro-Carrillo PJ, Teruel-Montoya R. Emerging Role of Neutrophils in the Thrombosis of Chronic Myeloproliferative Neoplasms. International Journal of Molecular Sciences. 2021; 22(3):1143. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031143

Chicago/Turabian Style

Ferrer-Marín, Francisca; Cuenca-Zamora, Ernesto J.; Guijarro-Carrillo, Pedro J.; Teruel-Montoya, Raúl. 2021. "Emerging Role of Neutrophils in the Thrombosis of Chronic Myeloproliferative Neoplasms" Int. J. Mol. Sci. 22, no. 3: 1143. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031143

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