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Open AccessArticle

The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (Beta vulgaris L.) Betalain-Rich Extract to Hypochlorous Acid

1
Department of Analytical Chemistry, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 31-155 Kraków, Poland
2
Research and Analytical Center, VDF FutureCeuticals, Inc., 2692 N. State Rt. 1-17, Momence, IL 60954, USA
3
Food Science & Human Nutrition, University of Illinois at Urbana-Champaign, 260 Bevier Hall, 905 S Goodwin Ave, Urbana, IL 61801, USA
4
Discovery Research Lab, VDF FutureCeuticals, Inc., 23 Peters Canyon Rd, Irvine, CA 92606, USA
5
NanoBioMedical Centre, Adam Mickiewicz University in Poznań, Wszechnicy Piastowskiej 3, 61-614 Poznań, Poland
6
Department of Applied Chemistry, National Chiao Tung University, Hsinchu 300, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(3), 1155; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031155
Received: 22 December 2020 / Revised: 15 January 2021 / Accepted: 17 January 2021 / Published: 25 January 2021
(This article belongs to the Special Issue Biological Properties of Medicinal Plants)
Neutrophils produce hypochlorous acid (HOCl) as well as other reactive oxygen species as part of a natural innate immune response in the human body; however, excessive levels of HOCl can ultimately be detrimental to health. Recent reports suggest that betacyanin plant pigments can act as potent scavengers of inflammatory factors and are notably effective against HOCl. Comparison of the in vitro anti-hypochlorite activities of a novel betalain-rich red beetroot (Beta vulgaris L.) extract with its pure betalainic pigments revealed that the extract had the highest anti-hypochlorite activity, far exceeding the activity of all of the betalainic derivatives and selected reference antioxidants. This suggests that it may be an important food-based candidate for management of inflammatory conditions induced by excessive HOCl production. Among all pigments studied, betanidin exhibited the highest activity across the pH range. View Full-Text
Keywords: betacyanins; betalain rich extract; inflammation; hypochlorite scavenging betacyanins; betalain rich extract; inflammation; hypochlorite scavenging
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MDPI and ACS Style

Starzak, K.; Sutor, K.; Świergosz, T.; Nemzer, B.; Pietrzkowski, Z.; Popenda, Ł.; Liu, S.-R.; Wu, S.-P.; Wybraniec, S. The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (Beta vulgaris L.) Betalain-Rich Extract to Hypochlorous Acid. Int. J. Mol. Sci. 2021, 22, 1155. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031155

AMA Style

Starzak K, Sutor K, Świergosz T, Nemzer B, Pietrzkowski Z, Popenda Ł, Liu S-R, Wu S-P, Wybraniec S. The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (Beta vulgaris L.) Betalain-Rich Extract to Hypochlorous Acid. International Journal of Molecular Sciences. 2021; 22(3):1155. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031155

Chicago/Turabian Style

Starzak, Karolina; Sutor, Katarzyna; Świergosz, Tomasz; Nemzer, Boris; Pietrzkowski, Zbigniew; Popenda, Łukasz; Liu, Shi-Rong; Wu, Shu-Pao; Wybraniec, Sławomir. 2021. "The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (Beta vulgaris L.) Betalain-Rich Extract to Hypochlorous Acid" Int. J. Mol. Sci. 22, no. 3: 1155. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031155

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