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Multiomics Integration in Skin Diseases with Alterations in Notch Signaling Pathway: PlatOMICs Phase 1 Deployment

1
Department of Advanced Diagnostics, Institute for Maternal and Child Health IRCCS Burlo Garofolo, 34137 Trieste, Italy
2
Department of Pathology, Federal University of Pernambuco (UFPE), Recife 1235, Brazil
3
Department of Biological and Environmental Sciences, College of Arts and Sciences, University of Qatar, Doha 2713, Qatar
*
Author to whom correspondence should be addressed.
Academic Editors: Kalevi Kairemo and Ancha Baranova
Int. J. Mol. Sci. 2021, 22(4), 1523; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22041523
Received: 17 December 2020 / Revised: 28 January 2021 / Accepted: 1 February 2021 / Published: 3 February 2021
(This article belongs to the Special Issue OMICs, Data Integration, and Applications in Personalized Medicine)
The high volume of information produced in the age of omics was and still is an important step to understanding several pathological processes, providing the enlightenment of complex molecular networks and the identification of molecular targets associated with many diseases. Despite these remarkable scientific advances, the majority of the results are disconnected and divergent, making their use limited. Skin diseases with alterations in the Notch signaling pathway were extensively studied during the omics era. In the GWAS Catalog, considering only studies on genomics association (GWAS), several works were deposited, some of which with divergent results. In addition, there are thousands of scientific articles available about these skin diseases. In our study, we focused our attention on skin diseases characterized by the impairment of Notch signaling, this pathway being of pivotal importance in the context of epithelial disorders. We considered the pathologies of five human skin diseases, Hidradenitis Suppurativa, Dowling Degos Disease, Adams–Oliver Syndrome, Psoriasis, and Atopic Dermatitis, in which the molecular alterations in the Notch signaling pathway have been reported. To this end, we started developing a new multiomics platform, PlatOMICs, to integrate and re-analyze omics information, searching for the molecular interactions involved in the pathogenesis of skin diseases with alterations in the Notch signaling pathway. View Full-Text
Keywords: omics; genomics; transcriptomics; proteomics; network interaction; skin diseases omics; genomics; transcriptomics; proteomics; network interaction; skin diseases
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MDPI and ACS Style

Brandão, L.A.C.; Tricarico, P.M.; Gratton, R.; Agrelli, A.; Zupin, L.; Abou-Saleh, H.; Moura, R.; Crovella, S. Multiomics Integration in Skin Diseases with Alterations in Notch Signaling Pathway: PlatOMICs Phase 1 Deployment. Int. J. Mol. Sci. 2021, 22, 1523. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22041523

AMA Style

Brandão LAC, Tricarico PM, Gratton R, Agrelli A, Zupin L, Abou-Saleh H, Moura R, Crovella S. Multiomics Integration in Skin Diseases with Alterations in Notch Signaling Pathway: PlatOMICs Phase 1 Deployment. International Journal of Molecular Sciences. 2021; 22(4):1523. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22041523

Chicago/Turabian Style

Brandão, Lucas A.C., Paola M. Tricarico, Rossella Gratton, Almerinda Agrelli, Luisa Zupin, Haissam Abou-Saleh, Ronald Moura, and Sergio Crovella. 2021. "Multiomics Integration in Skin Diseases with Alterations in Notch Signaling Pathway: PlatOMICs Phase 1 Deployment" International Journal of Molecular Sciences 22, no. 4: 1523. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22041523

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