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Review

Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis

1
Department of Neonatology, Saint-Petersburg State Pediatric Medical University, Litovskaya Ulitsa, 2, St. Petersburg 194100, Russia
2
Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleyevskaya Liniya, 3, St. Petersburg 199034, Russia
3
Saint Petersburg Institute of Bioregulation and Gerontology, Dynamo Ave., 3, St. Petersburg 197110, Russia
4
Saint-Petersburg Research Institute of Phthisiopulmonology, Lygovsky Ave., 2-4, St. Petersburg 191036, Russia
5
Department of Pathology, Saint-Petersburg State University, University Embankment, 7/9, St. Petersburg 199034, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Tommaso Aversa
Int. J. Mol. Sci. 2021, 22(4), 2058; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22042058
Received: 11 January 2021 / Revised: 8 February 2021 / Accepted: 15 February 2021 / Published: 19 February 2021
The review summarizes the results of experimental and clinical studies aimed at elucidating the causes and pathophysiological mechanisms of the development of endocrine pathology in children. The modern data on the role of epigenetic influences in the early ontogenesis of unfavorable factors that violate the patterns of the formation of regulatory mechanisms during periods of critical development of fetal organs and systems and contribute to the delayed development of pathological conditions are considered. The mechanisms of the participation of melatonin in the regulation of metabolic processes and the key role of maternal melatonin in the formation of the circadian system of regulation in the fetus and in the protection of the genetic program of its morphofunctional development during pregnancy complications are presented. Melatonin, by controlling DNA methylation and histone modification, prevents changes in gene expression that are directly related to the programming of endocrine pathology in offspring. Deficiency and absence of the circadian rhythm of maternal melatonin underlies violations of the genetic program for the development of hormonal and metabolic regulatory mechanisms of the functional systems of the child, which determines the programming and implementation of endocrine pathology in early ontogenesis, contributing to its development in later life. The significance of this factor in the pathophysiological mechanisms of endocrine disorders determines a new approach to risk assessment and timely prevention of offspring diseases even at the stage of family planning. View Full-Text
Keywords: melatonin; endocrine pathology; children; early ontogenesis; family planning melatonin; endocrine pathology; children; early ontogenesis; family planning
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MDPI and ACS Style

Ivanov, D.O.; Evsyukova, I.I.; Mironova, E.S.; Polyakova, V.O.; Kvetnoy, I.M.; Nasyrov, R.A. Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis. Int. J. Mol. Sci. 2021, 22, 2058. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22042058

AMA Style

Ivanov DO, Evsyukova II, Mironova ES, Polyakova VO, Kvetnoy IM, Nasyrov RA. Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis. International Journal of Molecular Sciences. 2021; 22(4):2058. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22042058

Chicago/Turabian Style

Ivanov, Dmitry O., Inna I. Evsyukova, Ekaterina S. Mironova, Victoria O. Polyakova, Igor M. Kvetnoy, and Ruslan A. Nasyrov 2021. "Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis" International Journal of Molecular Sciences 22, no. 4: 2058. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22042058

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