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Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet

Department of Cardio-Renal Physiopathology, INC Ignacio Chávez, Mexico City 14080, Mexico
Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM), Mexico City 04510, Mexico
Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO 80045, USA
Authors to whom correspondence should be addressed.
Academic Editor: Enrique Barrajon
Int. J. Mol. Sci. 2021, 22(5), 2431;
Received: 25 January 2021 / Revised: 23 February 2021 / Accepted: 24 February 2021 / Published: 28 February 2021
(This article belongs to the Special Issue Bioactives and Nutraceuticals in Metabolic Syndrome 2021)
Excessive intake of fructose results in metabolic syndrome (MS) and kidney damage, partly mediated by its metabolism by fructokinase-C or ketohexokinase-C (KHK-C). Osthol has antioxidant properties, is capable of regulating adipogenesis, and inhibits KHK-C activity. Here, we examined the potential protective role of osthol in the development of kidney disease induced by a Western (high-fat/high-sugar) diet. Control rats fed with a high-fat/high-sugar diet were compared with two groups that also received two different doses of osthol (30 mg/kg/d or 40 mg/kg/d body weight BW). A fourth group served as a normal control and received regular chow. At the end of the follow-up, kidney function, metabolic markers, oxidative stress, and lipogenic enzymes were evaluated. The Western diet induced MS (hypertension, hyperglycemia, hypertriglyceridemia, obesity, hyperuricemia), a fall in the glomerular filtration rate, renal tubular damage, and increased oxidative stress in the kidney cortex, with increased expression of lipogenic enzymes and increased kidney KHK expression. Osthol treatment prevented the development of MS and ameliorated kidney damage by inhibiting KHK activity, preventing oxidative stress via nuclear factor erythroid 2-related factor (Nrf2) activation, and reducing renal lipotoxicity. These data suggest that the nutraceutical osthol might be an ancillary therapy to slow the progression of MS and kidney damage induced by a Western diet. View Full-Text
Keywords: metabolic syndrome; renal lipotoxicity; fructokinase; coumarins metabolic syndrome; renal lipotoxicity; fructokinase; coumarins
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MDPI and ACS Style

García-Arroyo, F.E.; Gonzaga-Sánchez, G.; Tapia, E.; Muñoz-Jiménez, I.; Manterola-Romero, L.; Osorio-Alonso, H.; Arellano-Buendía, A.S.; Pedraza-Chaverri, J.; Roncal-Jiménez, C.A.; Lanaspa, M.A.; Johnson, R.J.; Sánchez-Lozada, L.G. Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet. Int. J. Mol. Sci. 2021, 22, 2431.

AMA Style

García-Arroyo FE, Gonzaga-Sánchez G, Tapia E, Muñoz-Jiménez I, Manterola-Romero L, Osorio-Alonso H, Arellano-Buendía AS, Pedraza-Chaverri J, Roncal-Jiménez CA, Lanaspa MA, Johnson RJ, Sánchez-Lozada LG. Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet. International Journal of Molecular Sciences. 2021; 22(5):2431.

Chicago/Turabian Style

García-Arroyo, Fernando E.; Gonzaga-Sánchez, Guillermo; Tapia, Edilia; Muñoz-Jiménez, Itzel; Manterola-Romero, Lino; Osorio-Alonso, Horacio; Arellano-Buendía, Abraham S.; Pedraza-Chaverri, José; Roncal-Jiménez, Carlos A.; Lanaspa, Miguel A.; Johnson, Richard J.; Sánchez-Lozada, Laura G. 2021. "Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet" Int. J. Mol. Sci. 22, no. 5: 2431.

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