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Review

Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions

1
Kolling Institute, Faculty of Medicine and Health, University of Sydney, St. Leonards, NSW 2065, Australia
2
Faculty of Medicine and Health, School of Medical Sciences, University of Sydney, Camperdown, NSW 2006, Australia
3
Faculty of Science, School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia
4
Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China
5
Faculty of Engineering and IT, School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia
*
Author to whom correspondence should be addressed.
Academic Editors: Andreas Spittler, Wolfgang Holnthoner and Viktoria Weber
Int. J. Mol. Sci. 2021, 22(6), 3023; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063023
Received: 19 February 2021 / Revised: 6 March 2021 / Accepted: 12 March 2021 / Published: 16 March 2021
(This article belongs to the Special Issue Extracellular Vesicles in Inflammation)
Over the past two decades, mesenchymal stromal cells (MSCs) have demonstrated great potential in the treatment of inflammation-related conditions. Numerous early stage clinical trials have suggested that this treatment strategy has potential to lead to significant improvements in clinical outcomes. While promising, there remain substantial regulatory hurdles, safety concerns, and logistical issues that need to be addressed before cell-based treatments can have widespread clinical impact. These drawbacks, along with research aimed at elucidating the mechanisms by which MSCs exert their therapeutic effects, have inspired the development of extracellular vesicles (EVs) as anti-inflammatory therapeutic agents. The use of MSC-derived EVs for treating inflammation-related conditions has shown therapeutic potential in both in vitro and small animal studies. This review will explore the current research landscape pertaining to the use of MSC-derived EVs as anti-inflammatory and pro-regenerative agents in a range of inflammation-related conditions: osteoarthritis, rheumatoid arthritis, Alzheimer’s disease, cardiovascular disease, and preeclampsia. Along with this, the mechanisms by which MSC-derived EVs exert their beneficial effects on the damaged or degenerative tissues will be reviewed, giving insight into their therapeutic potential. Challenges and future perspectives on the use of MSC-derived EVs for the treatment of inflammation-related conditions will be discussed. View Full-Text
Keywords: mesenchymal stromal cells; extracellular vesicles; inflammation; regeneration; osteoarthritis; rheumatoid arthritis; Alzheimer’s disease; cardiovascular disease; preeclampsia mesenchymal stromal cells; extracellular vesicles; inflammation; regeneration; osteoarthritis; rheumatoid arthritis; Alzheimer’s disease; cardiovascular disease; preeclampsia
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MDPI and ACS Style

Ryan, S.T.; Hosseini-Beheshti, E.; Afrose, D.; Ding, X.; Xia, B.; Grau, G.E.; Little, C.B.; McClements, L.; Li, J.J. Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions. Int. J. Mol. Sci. 2021, 22, 3023. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063023

AMA Style

Ryan ST, Hosseini-Beheshti E, Afrose D, Ding X, Xia B, Grau GE, Little CB, McClements L, Li JJ. Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions. International Journal of Molecular Sciences. 2021; 22(6):3023. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063023

Chicago/Turabian Style

Ryan, Sean T., Elham Hosseini-Beheshti, Dinara Afrose, Xianting Ding, Binbin Xia, Georges E. Grau, Christopher B. Little, Lana McClements, and Jiao J. Li 2021. "Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions" International Journal of Molecular Sciences 22, no. 6: 3023. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063023

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